| Cell line name |
AGS/EPI |
|---|
| Accession |
CVCL_Y085 |
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| Resource Identification Initiative |
To cite this cell line use: AGS/EPI (RRID:CVCL_Y085) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_47898; 4'-epidoxorubicin (Epirubicin).
Derived from site: In situ; Stomach; UBERON=UBERON_0000945. |
|---|
| Sequence variations |
- Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gly34Glu (c.101G>A); ClinVar=VCV000017584; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu453Lys (c.1357G>A); ClinVar=VCV000376470; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Ala (c.1634A>C); ClinVar=VCV000013659; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:667; RHOA; Simple; p.Glu64del (c.192_194del); Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Gastric adenocarcinoma (NCIt: C4004) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_0139 (AGS) |
|---|
| Sex of cell |
Female |
|---|
| Age at sampling |
54Y |
|---|
| Category |
Cancer cell line |
|---|
| Publications | PubMed=25169536; DOI=10.7314/APJCP.2014.15.16.6849
Aledson Vitor Felipe, Andrea Aparecida Moraes, Juliana de Oliveira, Tiago Donizetti da Silva, Nora Manoukian Forones;
Establishment and partial characterization of an epirubicin-resistant gastric cancer cell line with upregulated ABCB1.
Asian Pac. J. Cancer Prev. 15:6849-6853(2014) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_Y085
|
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| Encyclopedic resources |
Wikidata; Q54748717
|
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| Entry history |
|---|
| Entry creation | 07-Nov-2014 |
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| Last entry update | 14-Aug-2025 |
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| Version number | 14 |
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