Cellosaurus cell line U87MG Human EGFR vIII (CVCL

Cross-references
Cell line name	U87MG Human EGFR vIII
Accession	CVCL_XZ66
Resource Identification Initiative	To cite this cell line use: U87MG Human EGFR vIII (RRID:CVCL_XZ66)
Comments	Problematic cell line: Misidentified. Parent cell line (U-87MG ATCC) is not the original glioblastoma cell line established in 1968 at the University of Uppsala. Population: Caucasian. Doubling time: ~30 hours (KYinno=KC-1308). Transfected with: HGNC; 3236; EGFR (with p.Val30_Arg297del = EGFRvIII). Transfected with: UniProtKB; P13249; S.alboniger pac (PuroR).
Sequence variations	Mutation; HGNC; 7765; NF1; Simple; p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT); ClinVar=VCV000420078; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; 9588; PTEN; Simple; c.209+1G>T; ClinVar=VCV000229705; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line). Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease	Glioblastoma (NCIt: C3058) Glioblastoma (ORDO: Orphanet_360)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0022 (U-87MG ATCC)
Sex of cell	Male
Age at sampling	Age unspecified
Category	Cancer cell line
Cell line collections (Providers)	KYinno; KC-1308
Cell line databases/resources	cancercelllines; CVCL_XZ66
Encyclopedic resources	Wikidata; Q98133791
Entry history
Entry creation	19-Dec-2019
Last entry update	05-Oct-2023
Version number	8