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Cellosaurus RPMI-8226-R (CVCL_XK17)

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Cell line name RPMI-8226-R
Synonyms RPMI 8226-R; RPMI 8226R
Accession CVCL_XK17
Resource Identification Initiative To cite this cell line use: RPMI-8226-R (RRID:CVCL_XK17)
Comments Population: African American.
Characteristics: Produces IgG lambda (from parent cell line).
Selected for resistance to: ChEBI; CHEBI_52717; Bortezomib (Velcade).
Omics: Proteomics; Quantitative.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: Plasma cell; CL=CL_0000786.
Sequence variations
  • Gene fusion; HGNC; HGNC:5722; IGKJ4 + HGNC; HGNC:5783; IGKV2-28; Name(s)=IGKV2-28-IGKJ4 (from parent cell line).
  • Gene fusion; HGNC; HGNC:5865; IGLJ3 + HGNC; HGNC:5888; IGLV2-14; Name(s)=IGLV2-14-IGLJ3 (from parent cell line).
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Thr751Ile (c.2252C>T); ClinVar=VCV000177773; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu285Lys (c.853G>A); ClinVar=VCV000420133; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:12033; TRAF3; Simple; p.Lys191Leufs*60; Zygosity=Unspecified (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0014 (RPMI-8226)
Sex of cell Male
Age at sampling 61Y
Category Cancer cell line
Publications

PubMed=31465861; DOI=10.1016/j.jprot.2019.103504
Venkatesh Chanukuppa, Debasish Paul, Khushman Taunk, Tathagata Chatterjee, Sanjeevan Sharma, Saravanan Kumar, Manas K. Santra, Srikanth Rapole;
XPO1 is a critical player for bortezomib resistance in multiple myeloma: a quantitative proteomic approach.
J. Proteomics 209:103504.1-103504.10(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_XK17
Encyclopedic resources Wikidata; Q98129177
Proteomic databases PRIDE; PXD013859
Entry history
Entry creation19-Dec-2019
Last entry update14-Aug-2025
Version number11