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Cellosaurus HepG2-CYP2B6-hCAR (CVCL_XI69)

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Cell line name HepG2-CYP2B6-hCAR
Accession CVCL_XI69
Resource Identification Initiative To cite this cell line use: HepG2-CYP2B6-hCAR (RRID:CVCL_XI69)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:2615; CYP2B6.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:7969; NR1I3.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P33967; Bacillus cereus Bsr.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase (Note=With optimized codon usage for mammalian expression).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=25993555; DOI=10.1038/srep10405; PMCID=PMC4438668
Caitlin Lynch, Jing-Hua Zhao, Rui-Li Huang, Jing-Wei Xiao, Lin-Hao Li, Scott Heyward, Meng-Hang Xia, Hong-Bing Wang;
Quantitative high-throughput identification of drugs as modulators of human constitutive androstane receptor.
Sci. Rep. 5:10405.1-10405.14(2015)

PubMed=27518621; DOI=10.1007/978-1-4939-6346-1_4; PMCID=PMC5341601
Caitlin Lynch, Jing-Hua Zhao, Hong-Bing Wang, Meng-Hang Xia;
Quantitative high-throughput luciferase screening in identifying CAR modulators.
Methods Mol. Biol. 1473:33-42(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_XI69
Encyclopedic resources Wikidata; Q94103346
Entry history
Entry creation19-Dec-2019
Last entry update14-Aug-2025
Version number13