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Cellosaurus PH3MT (CVCL_XG28)

[Text version]
Cell line name PH3MT
Accession CVCL_XG28
Resource Identification Initiative To cite this cell line use: PH3MT (RRID:CVCL_XG28)
Comments Characteristics: Growth factor-independent, form large-sized colonies in agarose and form fibrosarcomas in athymic mice at the site of injection with a very short latency.
Characteristics: Derived from a tumor formed in athymic mice by injection of the parent cell line.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P01110; Avian myelocytomatosis virus MC29 v-Myc.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: v-Myc.
Derived from site: In situ; Foreskin, skin; UBERON=UBERON_0001471.
Cell type: Fibroblast of foreskin; CL=CL_1001608.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_XG26 (MSU-1.1-T24 3)
Sex of cell Male
Age at sampling <1M
Category Transformed cell line
Publications

PubMed=11888918
Havre P.A., O'Reilly S., McCormick J.J., Brash D.E.
Transformed and tumor-derived human cells exhibit preferential sensitivity to the thiol antioxidants, N-acetyl cysteine and penicillamine.
Cancer Res. 62:1443-1449(2002)

PubMed=18048363; DOI=10.1074/jbc.M709046200
Lito P., Mets B.D., Kleff S., O'Reilly S., Maher V.M., McCormick J.J.
Evidence that sprouty 2 is necessary for sarcoma formation by H-Ras oncogene-transformed human fibroblasts.
J. Biol. Chem. 283:2002-2009(2008)

PubMed=19008219; DOI=10.1074/jbc.M808045200; PMCID=PMC2613613
Lito P., Mets B.D., Appledorn D.M., Maher V.M., McCormick J.J.
Sprouty 2 regulates DNA damage-induced apoptosis in Ras-transformed human fibroblasts.
J. Biol. Chem. 284:848-854(2009)

Cross-references
Encyclopedic resources Wikidata; Q98128571
Entry history
Entry creation06-Sep-2019
Last entry update19-Dec-2024
Version number8