Cellosaurus cell line PH3MT (CVCL

Cellosaurus PH3MT (CVCL_XG28)

Cross-references
Cell line name	PH3MT
Accession	CVCL_XG28
Resource Identification Initiative	To cite this cell line use: PH3MT (RRID:CVCL_XG28)
Comments	Characteristics: Growth factor-independent, form large-sized colonies in agarose and form fibrosarcomas in athymic mice at the site of injection with a very short latency. Characteristics: Derived from a tumor formed in athymic mice by injection of the parent cell line. Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val). Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P01110; Avian myelocytomatosis virus 29 v-Myc. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo. Transformant: v-Myc. Derived from site: In situ; Foreskin, skin; UBERON=UBERON_0001471. Cell type: Fibroblast of foreskin; CL=CL_1001608.
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_XG26 (MSU-1.1-T24 3)
Sex of cell	Male
Age at sampling	<1M
Category	Transformed cell line
Publications	PubMed=11888918 Pamela A. Havre, Sandra O'Reilly, J. Justin McCormick, Douglas E. Brash; Transformed and tumor-derived human cells exhibit preferential sensitivity to the thiol antioxidants, N-acetyl cysteine and penicillamine. Cancer Res. 62:1443-1449(2002) PubMed=18048363; DOI=10.1074/jbc.M709046200 Piro Lito, Bryan D. Mets, Susanne Kleff, Sandra O'Reilly, Veronica M. Maher, J. Justin McCormick; Evidence that sprouty 2 is necessary for sarcoma formation by H-Ras oncogene-transformed human fibroblasts. J. Biol. Chem. 283:2002-2009(2008) PubMed=19008219; DOI=10.1074/jbc.M808045200; PMCID=PMC2613613 Piro Lito, Bryan D. Mets, Daniel M. Appledorn, Veronica M. Maher, J. Justin McCormick; Sprouty 2 regulates DNA damage-induced apoptosis in Ras-transformed human fibroblasts. J. Biol. Chem. 284:848-854(2009)
Encyclopedic resources	Wikidata; Q98128571
Entry history
Entry creation	06-Sep-2019
Last entry update	14-Aug-2025
Version number	9