ID   PH3MT
AC   CVCL_XG28
DR   Wikidata; Q98128571
RX   PubMed=11888918;
RX   PubMed=18048363;
RX   PubMed=19008219;
CC   Characteristics: Growth factor-independent, form large-sized colonies in agarose and form fibrosarcomas in athymic mice at the site of injection with a very short latency.
CC   Characteristics: Derived from a tumor formed in athymic mice by injection of the parent cell line.
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P01110; Avian myelocytomatosis virus MC29 v-Myc.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: v-Myc.
CC   Derived from site: In situ; Foreskin, skin; UBERON=UBERON_0001471.
CC   Cell type: Fibroblast of foreskin; CL=CL_1001608.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_XG26 ! MSU-1.1-T24 3
SX   Male
AG   <1M
CA   Transformed cell line
DT   Created: 06-09-19; Last updated: 19-12-24; Version: 8
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RX   PubMed=11888918;
RA   Havre P.A., O'Reilly S., McCormick J.J., Brash D.E.;
RT   "Transformed and tumor-derived human cells exhibit preferential
RT   sensitivity to the thiol antioxidants, N-acetyl cysteine and
RT   penicillamine.";
RL   Cancer Res. 62:1443-1449(2002).
//
RX   PubMed=18048363; DOI=10.1074/jbc.M709046200;
RA   Lito P., Mets B.D., Kleff S., O'Reilly S., Maher V.M., McCormick J.J.;
RT   "Evidence that sprouty 2 is necessary for sarcoma formation by H-Ras
RT   oncogene-transformed human fibroblasts.";
RL   J. Biol. Chem. 283:2002-2009(2008).
//
RX   PubMed=19008219; DOI=10.1074/jbc.M808045200; PMCID=PMC2613613;
RA   Lito P., Mets B.D., Appledorn D.M., Maher V.M., McCormick J.J.;
RT   "Sprouty 2 regulates DNA damage-induced apoptosis in Ras-transformed
RT   human fibroblasts.";
RL   J. Biol. Chem. 284:848-854(2009).
//