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Cellosaurus (CVCL_XA84)

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Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Mutation; HGNC; HGNC:11100; SMARCA4; Simple; p.Arg1192Cys (c.3574C>T); ClinVar=VCV000570308; Zygosity=Heterozygous (Cosmic-CLP=910209; DepMap=ACH-002308).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly245Ser (c.733G>A); ClinVar=VCV000012365; Zygosity=Homozygous (DepMap=ACH-002308).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.05
Native American0
East Asian, North0.63
East Asian, South0.05
South Asian1.61
European, North69.66
European, South28
Disease Childhood B acute lymphoblastic leukemia (NCIt: C9140)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=910209

Markers:

Run an STR similarity search on this cell line
Publications



lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.
J. Exp. Med. 166:1229-1244(1987)


Paula D. Bos, Xiang H.-F. Zhang, Cristina Nadal, Wei-Ping Shu, Roger R. Gomis, Don X. Nguyen, Andy J. Minn, Marc Joan van de Vijver, William Levi Gerald, John A. Foekens, Joan Massague;
Genes that mediate breast cancer metastasis to the brain.
Nature 459:1005-1009(2009)


Yasuhiro Takashima, Ge Guo, Remco Loos, Jennifer Nichols, Gabriella Ficz, Felix Krueger, David Oxley, Fatima Santos, James Clarke, William Mansfield, Wolf Reik ...Show all 13 authors... , Paul Bertone, Austin Gerard Smith; Show fewer authors
Resetting transcription factor control circuitry toward ground-state pluripotency in human.
Cell 158:1254-1269(2014)



literature.
Cancer Res. 77:2784-2788(2017)




Cancer Cell 33:386-400.e5(2018)

Cross-references
Encyclopedic resources Wikidata; Q54970874
Proteomic databases PRIDE; PXD030304
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number33