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Cellosaurus PC9-LeptoM (CVCL_XA20)

[Text version]
Cell line name PC9-LeptoM
Synonyms PC9 LeptoM
Accession CVCL_XA20
Resource Identification Initiative To cite this cell line use: PC9-LeptoM (RRID:CVCL_XA20)
Comments Part of: Brain metastasis cell lines panel.
Population: Japanese.
Characteristics: Brain leptomeningeal space metastatic derivative of parental cell line. Established after 3 passages in nude mice from intracisternal injection, followed by one passage from intracardiac injection and obtained from mice bearing leptomeningeal metastases.
Characteristics: Transfected with HSV1-TK/GFP/Fluc (TGL).
Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
Transfected with: UniProtKB; P08659; Firefly luciferase.
Transfected with: UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_XA18 (PC9-TGL)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Web pages https://apps.cnio.es/app/BrainMetastasis/CellLines

PubMed=28283064; DOI=10.1016/j.cell.2017.02.025
Boire A., Zou Y.-L., Shieh J., Macalinao D.G., Pentsova E., Massague J.
Complement component 3 adapts the cerebrospinal fluid for leptomeningeal metastasis.
Cell 168:1101-1113.e13(2017)

Cell line databases/resources cancercelllines; CVCL_XA20
Encyclopedic resources Wikidata; Q98128512
Gene expression databases GEO; GSM2194124
GEO; GSM2194125
Entry history
Entry creation06-Sep-2019
Last entry update05-Oct-2023
Version number9