ID   PC9-LeptoM
AC   CVCL_XA20
SY   PC9 LeptoM
DR   cancercelllines; CVCL_XA20
DR   GEO; GSM2194124
DR   GEO; GSM2194125
DR   Wikidata; Q98128512
RX   PubMed=28283064;
WW   Info; BrMPanel; -; https://apps.cnio.es/app/BrainMetastasis/CellLines
CC   Part of: Brain metastasis cell lines panel.
CC   Population: Chinese; Han and Japanese.
CC   Characteristics: Brain leptomeningeal space metastatic derivative of parental cell line. Established after 3 passages in nude mice from intracisternal injection, followed by one passage from intracardiac injection and obtained from mice bearing leptomeningeal metastases.
CC   Characteristics: Transfected with HSV1-TK/GFP/Fluc (TGL).
CC   Sequence variation: Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_XA18 ! PC9-TGL
SX   Male
AG   45Y
CA   Cancer cell line
DT   Created: 06-09-19; Last updated: 14-08-25; Version: 13
//
RX   PubMed=28283064; DOI=10.1016/j.cell.2017.02.025; PMCID=PMC5405733;
RA   Boire, Adrienne
RA   Zou, Yi-Long
RA   Shieh, Jason
RA   Macalinao, Danilo G.
RA   Pentsova, Elena
RA   Massague, Joan
RT   "Complement component 3 adapts the cerebrospinal fluid for
RT   leptomeningeal metastasis.";
RL   Cell 168:1101-1113.e13(2017).
//