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Cellosaurus PC9-BrM3 (CVCL_XA19)

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Cell line name PC9-BrM3
Accession CVCL_XA19
Resource Identification Initiative To cite this cell line use: PC9-BrM3 (RRID:CVCL_XA19)
Comments Part of: Brain metastasis cell lines panel.
Population: Chinese; Han and Japanese.
Characteristics: Brain metastatic derivative of parental cell line. Established after 3 passages in nude mice from intracardial injection. Obtained from mice bearing brain tumors.
Characteristics: Transfected with HSV1-TK/GFP/Fluc (TGL).
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_XA18 (PC9-TGL)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Web pages Info; BrMPanel; -; https://apps.cnio.es/app/BrainMetastasis/CellLines
Publications

PubMed=19576624; DOI=10.1016/j.cell.2009.04.030; PMCID=PMC2742946
Don X. Nguyen, Anne C. Chiang, Xiang H.-F. Zhang, Juliet Y. Kim, Mark G. Kris, Marc Ladanyi, William Levi Gerald, Joan Massague;
WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis.
Cell 138:51-62(2009)

Cross-references
Cell line databases/resources cancercelllines; CVCL_XA19
Encyclopedic resources Wikidata; Q98128511
Gene expression databases GEO; GSM354013
GEO; GSM354014
GEO; GSM2194119
GEO; GSM2194120
GEO; GSM2194121
Entry history
Entry creation06-Sep-2019
Last entry update14-Aug-2025
Version number13