ID   PC9-BrM3
AC   CVCL_XA19
DR   cancercelllines; CVCL_XA19
DR   GEO; GSM354013
DR   GEO; GSM354014
DR   GEO; GSM2194119
DR   GEO; GSM2194120
DR   GEO; GSM2194121
DR   Wikidata; Q98128511
RX   PubMed=19576624;
WW   Info; BrMPanel; -; https://apps.cnio.es/app/BrainMetastasis/CellLines
CC   Part of: Brain metastasis cell lines panel.
CC   Population: Chinese; Han and Japanese.
CC   Characteristics: Brain metastatic derivative of parental cell line. Established after 3 passages in nude mice from intracardial injection. Obtained from mice bearing brain tumors.
CC   Characteristics: Transfected with HSV1-TK/GFP/Fluc (TGL).
CC   Sequence variation: Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Firefly luciferase.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_XA18 ! PC9-TGL
SX   Male
AG   45Y
CA   Cancer cell line
DT   Created: 06-09-19; Last updated: 10-04-25; Version: 12
//
RX   PubMed=19576624; DOI=10.1016/j.cell.2009.04.030; PMCID=PMC2742946;
RA   Nguyen D.X., Chiang A.C., Zhang X.H.-F., Kim J.Y., Kris M.G., Ladanyi M.,
RA   Gerald W.L., Massague J.;
RT   "WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma
RT   metastasis.";
RL   Cell 138:51-62(2009).
//