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Cellosaurus ZMAC-1 (CVCL_X750)

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Cell line name ZMAC-1
Synonyms UIMAC FBAL-A; FBAL-A; ZMAC; Zuckermann MACrophage-1
Accession CVCL_X750
Resource Identification Initiative To cite this cell line use: ZMAC-1 (RRID:CVCL_X750)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); PTA-8764.
Characteristics: CSF1 dependent.
Virology: Susceptible to infection by porcine reproductive and respiratory syndrome virus (PRRSV) (PubMed=22648044).
Doubling time: ~72 hours (Patent=US9169465).
Derived from site: In situ; Fetal lung, alveolus; UBERON=UBERON_0005597+UBERON_0002299.
Cell type: Alveolar macrophage; CL=CL_0000583.
Species of origin Sus scrofa (Pig) (NCBI Taxonomy: 9823)
Breed/subspecies: Landrace x Yorkshire x Duroc.
Sex of cell Sex unspecified
Age at sampling 58FD
Category Factor-dependent cell line
Web pages https://www.pork.org/research/a-study-on-the-feasibility-of-using-a-porcine-alveolar-macrophage-cell-line-to-produce-a-prrs-modified-live-virus-vaccine/

PubMed=22648044; DOI=10.1016/j.vetimm.2012.05.008
Calzada-Nova G., Husmann R.J., Schnitzlein W.M., Zuckermann F.A.
Effect of the host cell line on the vaccine efficacy of an attenuated porcine reproductive and respiratory syndrome virus.
Vet. Immunol. Immunopathol. 148:116-125(2012)

Zuckermann F.A.
Non-simian cells for growth of porcine reproductive and respiratory syndrome (PRRS) virus.
Patent number US9169465, 27-Oct-2015

PubMed=33268540; DOI=10.1128/jcm.01757-20
Yim-Im W., Huang H.-Y., Park J., Wang C., Calzada-Nova G., Gauger P., Harmon K., Main R., Zhang J.-Q.
Comparison of ZMAC and MARC-145 cell lines for improving porcine reproductive and respiratory syndrome virus isolation from clinical samples.
J. Clin. Microbiol. 59:e01757.20.1-e01757.20.15(2021)

Cell line collections (Providers) ATCC; PTA-8764
Encyclopedic resources Wikidata; Q54995968
Entry history
Entry creation05-Sep-2014
Last entry update29-Jun-2023
Version number11