Cellosaurus C3H/TLR4mut MEF (CVCL_X606)
| Cell line name | C3H/TLR4mut MEF |
|---|---|
| Accession | CVCL_X606 |
| Resource Identification Initiative | To cite this cell line use: C3H/TLR4mut MEF (RRID:CVCL_X606) |
| Comments | Characteristics: Stably express a NF-kappaB-inducible SEAP reporter construct that allows to monitor in a simple and convenient manner the activation of NF-kappaB. As C3H/HeJ mice are defective in LPS signaling due to a TLR4 p.Pro712His mutation these cells are not activated by TLR4 agonists (InvivoGen=mef-c3h4m). Genetic integration: Method=Transfection; Gene=HGNC; HGNC:439; ALPP. Genetic integration: Method=Transfection; Gene=UniProtKB; P33967; B.cereus Bsr. Derived from site: In situ; Embryo; UBERON=UBERON_0000922. Cell type: Fibroblast; CL=CL_0000057. |
| Species of origin | Mus musculus (Mouse)
(NCBI Taxonomy: 10090)
Breed/subspecies: C3H/HeJ. |
| Sex of cell | Sex unspecified |
| Age at sampling | Embryo |
| Category | Finite cell line |
| Web pages | Provider; InvivoGen; mef-c3h4m; https://www.invivogen.com/sites/default/files/invivogen/products/files/c3h_tlr4mut_tds.pdf |
| Cross-references | |
| Cell line collections (Providers) | InvivoGen; mef-c3h4m - Discontinued |
| Encyclopedic resources | Wikidata; Q54808165 |
| Entry history | |
| Entry creation | 05-Sep-2014 |
| Last entry update | 10-Apr-2025 |
| Version number | 10 |