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Cellosaurus T79-A3 (CVCL_X528)

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Cell line name T79-A3
Synonyms V79-NTRpuro
Accession CVCL_X528
Resource Identification Initiative To cite this cell line use: T79-A3 (RRID:CVCL_X528)
Comments Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P38489; Escherichia coli nitroreductase nfnB.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Cell type: Fibroblast of lung; CL=CL_0002553.
Sequence variations
  • Mutation; UniProtKB; O09185; Tp53; Simple; p.Leu133Gln (c.398T>A); Zygosity=Unspecified (from parent cell line).
  • Mutation; UniProtKB; O09185; Tp53; Simple; p.Cys135Trp (c.405C>G); Zygosity=Unspecified (from parent cell line).
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_2234 (V79)
Sex of cell Male
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=9111301; DOI=10.1021/jm960794l
Frank Friedlos, William Alexander Denny, Brian D. Palmer, Caroline J. Springer;
Mustard prodrugs for activation by Escherichia coli nitroreductase in gene-directed enzyme prodrug therapy.
J. Med. Chem. 40:1270-1275(1997)

PubMed=14997211; DOI=10.1038/sj.bjc.6601612; PMCID=PMC2409616
Nuala Ann Helsby, Dianne M. Ferry, Adam V. Patterson, Susan M. Pullen, William R. Wilson;
2-amino metabolites are key mediators of CB 1954 and SN 23862 bystander effects in nitroreductase GDEPT.
Br. J. Cancer 90:1084-1092(2004)

Cross-references
Encyclopedic resources Wikidata; Q54971619
Entry history
Entry creation05-Sep-2014
Last entry update10-Sep-2024
Version number13