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Cellosaurus A375-MA1 (CVCL_X494)

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Cell line name A375-MA1
Synonyms A375-M1; MA-1
Accession CVCL_X494
Resource Identification Initiative To cite this cell line use: A375-MA1 (RRID:CVCL_X494)
Comments Population: Caucasian.
Characteristics: Metastatic. Derived by intravenous injection of parental cells into nude mice and harvesting of the mung metastases.
Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0132 (A-375)
Children:
CVCL_X495 (A375-MA2)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3222

Markers:
AmelogeninX
CSF1PO11,12
D5S81812
D7S8209
D13S31711,14
D16S5399
TH018
TPOX8,10
vWA16,17

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Publications

PubMed=18505921; DOI=10.1158/1541-7786.MCR-07-0344; PMCID=PMC2756991
Lei Xu, Steven S. Shen, Yujin Hoshida, Aravind Subramanian, Ken Ross, Jean-Philippe Brunet, Stephan N. Wagner, Sridhar Ramaswamy, Jill P. Mesirov, Richard Olding Hynes;
Gene expression changes in an animal melanoma model correlate with aggressiveness of human melanoma metastases.
Mol. Cancer Res. 6:760-769(2008)

Cross-references
Cell line collections (Providers) ATCC; CRL-3222
Cell line databases/resources cancercelllines; CVCL_X494
Encyclopedic resources Wikidata; Q54606801
Entry history
Entry creation05-Sep-2014
Last entry update19-Dec-2024
Version number19