Cellosaurus cell line HBEC4-KT (CVCL

Cellosaurus HBEC4-KT (CVCL_X492)

Cross-references
Cell line name	HBEC4-KT
Synonyms	HBEC4 KT; HBEC 4-KT; HBEC4KT; HBEC4
Accession	CVCL_X492
Resource Identification Initiative	To cite this cell line use: HBEC4-KT (RRID:CVCL_X492)
Comments	Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT. Genetic integration: Method=Transduction; Gene=MGI; MGI:88357; Cdk4. Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo. Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR). Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR). Omics: Transcriptomics; Microarray. Omics: Transcriptomics; miRNA profiling; Microarray. Derived from site: In situ; Lung, bronchus, epithelium; UBERON=UBERON_0002031. Cell type: Epithelial cell of bronchus; CL=CL_0002328.
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Female
Age at sampling	71Y
Category	Telomerase immortalized cell line
Publications	PubMed=15604268; DOI=10.1158/0008-5472.CAN-04-3703 Ruben D. Ramirez, Shelley Sheridan, Luc Girard, Mitsuo Sato, Young Kim, Jon Pollack, Michael Peyton, Ying Zou, Jonathan M. Kurie, J. Michael DiMaio, Sara Milchgrub ...Show all 21 authors... , Alice L. Smith, Rhonda F. Souza, Laura Gilbey, Xi Zhang, Kenia G. Gandia, Melville B. Vaughan, Woodring Erik Wright, Adi F. Gazdar, Jerry W. Shay, John D. Minna; Show fewer authors Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins. Cancer Res. 64:9027-9034(2004) PubMed=20624269; DOI=10.1186/1756-9966-29-75; PMCID=PMC2907339 Li-Qin Du, Jeoffrey J. Schageman, Irnov Irnov, Luc Girard, Scott M. Hammond, John D. Minna, Adi F. Gazdar, Alexander Pertsemlidis; MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells and suggests a possible pathological relationship between SCLCs and NSCLCs. J. Exp. Clin. Cancer Res. 29:75.1-75.12(2010) PubMed=32586780; DOI=10.1016/j.resinv.2020.04.005 Mitsuo Sato, Jerry W. Shay, John D. Minna; Immortalized normal human lung epithelial cell models for studying lung cancer biology. Respir. Investig. 58:344-354(2020)
Encyclopedic resources	Wikidata; Q54881417
Gene expression databases	GEO; GSM171896 GEO; GSM253433 GEO; GSM794410
Entry history
Entry creation	05-Sep-2014
Last entry update	14-Aug-2025
Version number	21