Cellosaurus cell line HBEC2-KT (CVCL

Cellosaurus HBEC2-KT (CVCL_X490)

Cross-references
Cell line name	HBEC2-KT
Synonyms	HBEC2 KT; HBEC2KT; HBEC 2-KT; HBEC2 Cdk4-hTERT; HBEC2
Accession	CVCL_X490
Resource Identification Initiative	To cite this cell line use: HBEC2-KT (RRID:CVCL_X490)
Comments	Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT. Genetic integration: Method=Transduction; Gene=MGI; MGI:88357; Cdk4. Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR). Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo. Omics: Transcriptomics; Microarray. Omics: Transcriptomics; miRNA profiling; Microarray. Derived from site: In situ; Lung, bronchus, epithelium; UBERON=UBERON_0002031. Cell type: Epithelial cell of bronchus; CL=CL_0002328.
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_DH91 ! HBEC2-E
Sex of cell	Male
Age at sampling	68Y
Category	Telomerase immortalized cell line
Publications	PubMed=15604268; DOI=10.1158/0008-5472.CAN-04-3703 Ramirez R.D., Sheridan S., Girard L., Sato M., Kim Y., Pollack J., Peyton M., Zou Y., Kurie J.M., DiMaio J.M., Milchgrub S., Smith A.L., Souza R.F., Gilbey L., Zhang X., Gandia K.G., Vaughan M.B., Wright W.E., Gazdar A.F., Shay J.W., Minna J.D. Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins. Cancer Res. 64:9027-9034(2004) PubMed=20624269; DOI=10.1186/1756-9966-29-75; PMCID=PMC2907339 Du L.-Q., Schageman J.J., Irnov I., Girard L., Hammond S.M., Minna J.D., Gazdar A.F., Pertsemlidis A. MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells and suggests a possible pathological relationship between SCLCs and NSCLCs. J. Exp. Clin. Cancer Res. 29:75.1-75.12(2010)
Encyclopedic resources	Wikidata; Q54881394
Gene expression databases	GEO; GSM171893 GEO; GSM253436 GEO; GSM794408
Entry history
Entry creation	05-Sep-2014
Last entry update	10-Apr-2025
Version number	21