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Cellosaurus HBEC2-KT (CVCL_X490)

[Text version]
Cell line name HBEC2-KT
Synonyms HBEC2 KT; HBEC2KT; HBEC 2-KT; HBEC2 Cdk4-hTERT; HBEC2
Accession CVCL_X490
Resource Identification Initiative To cite this cell line use: HBEC2-KT (RRID:CVCL_X490)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=MGI; MGI:88357; Cdk4.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; miRNA profiling; Microarray.
Derived from site: In situ; Lung, bronchus, epithelium; UBERON=UBERON_0002031.
Cell type: Epithelial cell of bronchus; CL=CL_0002328.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_DH91 ! HBEC2-E
Sex of cell Male
Age at sampling 68Y
Category Telomerase immortalized cell line
Publications

PubMed=15604268; DOI=10.1158/0008-5472.CAN-04-3703
Ruben D. Ramirez, Shelley Sheridan, Luc Girard, Mitsuo Sato, Young Kim, Jon Pollack, Michael Peyton, Ying Zou, Jonathan M. Kurie, J. Michael DiMaio, Sara Milchgrub ...Show all 21 authors... , Alice L. Smith, Rhonda F. Souza, Laura Gilbey, Xi Zhang, Kenia G. Gandia, Melville B. Vaughan, Woodring Erik Wright, Adi F. Gazdar, Jerry W. Shay, John D. Minna; Show fewer authors
Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins.
Cancer Res. 64:9027-9034(2004)

PubMed=20624269; DOI=10.1186/1756-9966-29-75; PMCID=PMC2907339
Li-Qin Du, Jeoffrey J. Schageman, Irnov Irnov, Luc Girard, Scott M. Hammond, John D. Minna, Adi F. Gazdar, Alexander Pertsemlidis;
MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells and suggests a possible pathological relationship between SCLCs and NSCLCs.
J. Exp. Clin. Cancer Res. 29:75.1-75.12(2010)

Cross-references
Encyclopedic resources Wikidata; Q54881394
Gene expression databases GEO; GSM171893
GEO; GSM253436
GEO; GSM794408
Entry history
Entry creation05-Sep-2014
Last entry update14-Aug-2025
Version number22