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Cellosaurus HLE/2E1 (CVCL_X149)

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Cell line name HLE/2E1
Accession CVCL_X149
Resource Identification Initiative To cite this cell line use: HLE/2E1 (RRID:CVCL_X149)
Comments Population: Japanese.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:2631; CYP2E1.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Cell type: Epithelial cell; CL=CL_0000066.
Sequence variations
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly244Ala (c.731G>C); ClinVar=VCV000458560; Zygosity=Unspecified (from parent cell line).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1281 (HLE)
Sex of cell Male
Age at sampling 68Y
Category Cancer cell line
Publications

PubMed=11212141; DOI=10.1007/BF02577524
Isao Nozaki, Toshiya Tsuji, Masakiyo Sakaguchi, Yusuke Inoue, Ryuji Hirai, Akio Andou, Masahiro Miyazaki, Nobuyoshi Shimizu, Masayoshi Namba;
Establishment of a human hepatoma cell line, HLE/2E1, suitable for detection of p450 2E1-related cytotoxicity.
In Vitro Cell. Dev. Biol. Anim. 36:566-570(2000)

Cross-references
Cell line databases/resources cancercelllines; CVCL_X149
Encyclopedic resources Wikidata; Q54889849
Entry history
Entry creation17-Jul-2014
Last entry update19-Dec-2024
Version number16