Cellosaurus cell line KJON (CVCL

Cellosaurus KJON (CVCL_WZ45)

Cross-references
Cell line name	KJON
Accession	CVCL_WZ45
Resource Identification Initiative	To cite this cell line use: KJON (RRID:CVCL_WZ45)
Comments	Doubling time: ~72 hours (PubMed=27311012). Omics: Transcriptomics; Microarray. Omics: Variations; Array-based CGH. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: Plasma cell; CL=CL_0000786.
Sequence variations	Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gln61His (c.183A>C); ClinVar=VCV000177881; Zygosity=Unspecified (PubMed=27311012). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr234Ter (c.702C>A); Zygosity=Hemizygous (PubMed=27311012).
Disease	Plasma cell myeloma (NCIt: C3242) Multiple myeloma (ORDO: Orphanet_29073)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Female
Age at sampling	66Y
Category	Cancer cell line
Publications	PubMed=22806891; DOI=10.1182/blood-2011-08-371567 Toril Holien, Thea Kristin Vatsveen, Hanne Hella, Anders Waage, Anders Sundan; Addiction to c-MYC in multiple myeloma. Blood 120:2450-2453(2012) PubMed=23936203; DOI=10.1371/journal.pone.0070430; PMCID=PMC3729839 Rebekka Muller, Kristine Misund, Toril Holien, Siri Bachke, Karin Margaretha Gilljam, Thea Kristin Vatsveen, Torstein B. Ro, Emanuele Bellacchio, Anders Sundan, Marit Otterlei; Targeting proliferating cell nuclear antigen and its protein interactions induces apoptosis in multiple myeloma cells. PLoS ONE 8:e70430.1-e70430.12(2013) PubMed=27311012; DOI=10.1002/gcc.22388 Thea Kristin Vatsveen, Magne Borset, Aida Dikic, Er-Ming Tian, Francesca Micci, Ana H.B. Lid, Leonardo Andres Meza-Zepeda, Eivind Coward, Anders Waage, Anders Sundan, Walter Michael Kuehl, Toril Holien; VOLIN and KJON -- two novel hyperdiploid myeloma cell lines. Genes Chromosomes Cancer 55:890-901(2016)
Cell line databases/resources	cancercelllines; CVCL_WZ45
Encyclopedic resources	Wikidata; Q94339814
Entry history
Entry creation	06-Sep-2019
Last entry update	14-Aug-2025
Version number	12