ID   KJON
AC   CVCL_WZ45
DR   cancercelllines; CVCL_WZ45
DR   Wikidata; Q94339814
RX   PubMed=22806891;
RX   PubMed=23936203;
RX   PubMed=27311012;
CC   Doubling time: ~72 hours (PubMed=27311012).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gln61His (c.183A>C); ClinVar=VCV000177881; Zygosity=Unspecified (PubMed=27311012).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr234Ter (c.702C>A); Zygosity=Hemizygous (PubMed=27311012).
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; Array-based CGH.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: B-cell; CL=CL_0000236.
DI   NCIt; C3242; Plasma cell myeloma
DI   ORDO; Orphanet_29073; Multiple myeloma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   66Y
CA   Cancer cell line
DT   Created: 06-09-19; Last updated: 10-04-25; Version: 11
//
RX   PubMed=22806891; DOI=10.1182/blood-2011-08-371567;
RA   Holien T., Vatsveen T.K., Hella H., Waage A., Sundan A.;
RT   "Addiction to c-MYC in multiple myeloma.";
RL   Blood 120:2450-2453(2012).
//
RX   PubMed=23936203; DOI=10.1371/journal.pone.0070430; PMCID=PMC3729839;
RA   Muller R., Misund K., Holien T., Bachke S., Gilljam K.M.,
RA   Vatsveen T.K., Ro T.B., Bellacchio E., Sundan A., Otterlei M.;
RT   "Targeting proliferating cell nuclear antigen and its protein
RT   interactions induces apoptosis in multiple myeloma cells.";
RL   PLoS ONE 8:e70430.1-e70430.12(2013).
//
RX   PubMed=27311012; DOI=10.1002/gcc.22388;
RA   Vatsveen T.K., Borset M., Dikic A., Tian E.-M., Micci F., Lid A.H.B.,
RA   Meza-Zepeda L.A., Coward E., Waage A., Sundan A., Kuehl W.M.,
RA   Holien T.;
RT   "VOLIN and KJON -- two novel hyperdiploid myeloma cell lines.";
RL   Genes Chromosomes Cancer 55:890-901(2016).
//