| Cell line name |
22Rv1-SL |
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| Synonyms |
Stem-Like 22Rv1; 22Rv1-Stem Like |
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| Accession |
CVCL_WZ28 |
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| Resource Identification Initiative |
To cite this cell line use: 22Rv1-SL (RRID:CVCL_WZ28) |
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| Comments |
Population: Caucasian.
Characteristics: Reprogrammed to, maintained and propagated as cancer stem-like cells (CSCs) by growth in androgen-free neural/neural crest (N/NC) stem medium.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Prostate; UBERON=UBERON_0002367. |
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| Sequence variations |
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Leu597Arg (c.1790T>G); ClinVar=VCV000013968; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7133; KMT2D; Simple; p.Arg1252Ter (c.3754C>T); ClinVar=VCV000167228; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7133; KMT2D; Simple; p.Gln3158Ter (c.9472C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Gln546Arg (c.1637A>G); ClinVar=VCV000045466; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln331Arg (c.992A>G); ClinVar=VCV000421319; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Prostate carcinoma (NCIt: C4863) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_1045 (22Rv1) |
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| Sex of cell |
Male |
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| Age at sampling |
Adult |
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| Category |
Cancer cell line |
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| Publications | PubMed=28145883; DOI=10.18632/oncotarget.14850; PMCID=PMC5386661
Mannan Nouri, Josselin Caradec, Amy Anne Lubik, Na Li, Brett G. Hollier, Mandeep Takhar, Manuel Altimirano-Dimas, Meng-Qian Chen, Mani Roshan-Moniri, Miriam Butler, Melanie Lehman ...Show all 27 authors... , Jennifer L. Bishop, Sarah Truong, Shih-Chieh Huang, Dawn R. Cochrane, Michael Cox, Catherine Collins, Martin E. Gleave, Nicholas Erho, Mohamed Alshalafa, Elai Davicioni, Colleen Nelson, Cheryl Y. Gregory-Evans, R. Jeffrey Karnes, Robert Brian Jenkins, Eric A. Klein, Ralph Buttyan; Show fewer authors
Therapy-induced developmental reprogramming of prostate cancer cells and acquired therapy resistance.
Oncotarget 8:18949-18967(2017) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_WZ28
|
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| Encyclopedic resources |
Wikidata; Q93302231
|
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| Gene expression databases |
GEO; GSM1633320
GEO; GSM1633321
GEO; GSM1633322
|
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| Entry history |
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| Entry creation | 06-Sep-2019 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 11 |
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