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Cellosaurus VCaP-SL (CVCL_WZ27)

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Cell line name VCaP-SL
Synonyms Stem-Like VCaP; VCaP-Stem Like
Accession CVCL_WZ27
Resource Identification Initiative To cite this cell line use: VCaP-SL (RRID:CVCL_WZ27)
Comments Population: Caucasian.
Characteristics: Reprogrammed to, maintained and propagated as cancer stem-like cells (CSCs) by growth in androgen-free neural/neural crest (N/NC) stem medium.
Virology: Contains an integrated xenotropic MuLV-related virus (XMRV) Bxv-1 (from parent cell line).
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Bone, vertebra; UBERON=UBERON_0002412.
Sequence variations
  • Gene fusion; HGNC; HGNC:3446; ERG + HGNC; HGNC:11876; TMPRSS2; Name(s)=TMPRSS2-ERG (from parent cell line).
  • Mutation; HGNC; HGNC:7127; MLH1; Simple; p.Ile219Val (c.655A>G); ClinVar=VCV000036557; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Homozygous (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2235 (VCaP)
Sex of cell Male
Age at sampling 59Y
Category Cancer cell line
Publications

PubMed=28145883; DOI=10.18632/oncotarget.14850; PMCID=PMC5386661
Mannan Nouri, Josselin Caradec, Amy Anne Lubik, Na Li, Brett G. Hollier, Mandeep Takhar, Manuel Altimirano-Dimas, Meng-Qian Chen, Mani Roshan-Moniri, Miriam Butler, Melanie Lehman ...Show all 27 authors... , Jennifer L. Bishop, Sarah Truong, Shih-Chieh Huang, Dawn R. Cochrane, Michael Cox, Catherine Collins, Martin E. Gleave, Nicholas Erho, Mohamed Alshalafa, Elai Davicioni, Colleen C. Nelson, Cheryl Y. Gregory-Evans, R. Jeffrey Karnes, Robert Brian Jenkins, Eric A. Klein, Ralph Buttyan; Show fewer authors
Therapy-induced developmental reprogramming of prostate cancer cells and acquired therapy resistance.
Oncotarget 8:18949-18967(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_WZ27
Encyclopedic resources Wikidata; Q98134496
Gene expression databases GEO; GSM1633314
GEO; GSM1633315
GEO; GSM1633316
Entry history
Entry creation06-Sep-2019
Last entry update10-Apr-2025
Version number14