ID   VCaP-SL
AC   CVCL_WZ27
SY   Stem-Like VCaP; VCaP-Stem Like
DR   cancercelllines; CVCL_WZ27
DR   GEO; GSM1633314
DR   GEO; GSM1633315
DR   GEO; GSM1633316
DR   Wikidata; Q98134496
RX   PubMed=28145883;
CC   Population: Caucasian.
CC   Characteristics: Reprogrammed to, maintained and propagated as cancer stem-like cells (CSCs) by growth in androgen-free neural/neural crest (N/NC) stem medium.
CC   Virology: Contains an integrated xenotropic MuLV-related virus (XMRV) Bxv-1 (from parent cell line).
CC   Sequence variation: Gene fusion; HGNC; HGNC:3446; ERG + HGNC; HGNC:11876; TMPRSS2; Name(s)=TMPRSS2-ERG (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7127; MLH1; Simple; p.Ile219Val (c.655A>G); ClinVar=VCV000036557; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Homozygous (from parent cell line).
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: Metastatic; Bone, vertebra; UBERON=UBERON_0002412.
DI   NCIt; C4863; Prostate carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2235 ! VCaP
SX   Male
AG   59Y
CA   Cancer cell line
DT   Created: 06-09-19; Last updated: 10-04-25; Version: 14
//
RX   PubMed=28145883; DOI=10.18632/oncotarget.14850; PMCID=PMC5386661;
RA   Nouri, Mannan
RA   Caradec, Josselin
RA   Lubik, Amy Anne
RA   Li, Na
RA   Hollier, Brett G.
RA   Takhar, Mandeep
RA   Altimirano-Dimas, Manuel
RA   Chen, Meng-Qian
RA   Roshan-Moniri, Mani
RA   Butler, Miriam
RA   Lehman, Melanie
RA   Bishop, Jennifer L.
RA   Truong, Sarah
RA   Huang, Shih-Chieh
RA   Cochrane, Dawn R.
RA   Cox, Michael
RA   Collins, Catherine
RA   Gleave, Martin E.
RA   Erho, Nicholas
RA   Alshalafa, Mohamed
RA   Davicioni, Elai
RA   Nelson, Colleen C.
RA   Gregory-Evans, Cheryl Y.
RA   Karnes, R. Jeffrey
RA   Jenkins, Robert Brian
RA   Klein, Eric A.
RA   Buttyan, Ralph
RT   "Therapy-induced developmental reprogramming of prostate cancer cells
RT   and acquired therapy resistance.";
RL   Oncotarget 8:18949-18967(2017).
//