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Cellosaurus AT2BR (CVCL_WY25)

[Text version]
Cell line name AT2BR
Synonyms Ataxia Telangiectasia 2 BRighton
Accession CVCL_WY25
Resource Identification Initiative To cite this cell line use: AT2BR (RRID:CVCL_WY25)
Comments Population: Caucasian; Irish.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
  • Mutation; HGNC; HGNC:795; ATM; Simple; p.Arg2547_Ser2549del (c.7638_7646delTAGAATTTC) (7636del9); ClinVar=VCV000003019; Zygosity=Homozygous (PubMed=7792600).
Disease Ataxia telangiectasia syndrome (NCIt: C2887)
Ataxia telangiectasia (ORDO: Orphanet_100)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_2564 ! AT2BR LCL
Sex of cell Female
Age at sampling 13Y
Category Finite cell line
Publications

PubMed=2903889; DOI=10.1080/09553008814552321
Colin Francis Arlett, Michael H.L. Green, Anne Priestley, Susan A. Harcourt, Lynne V. Mayne;
Comparative human cellular radiosensitivity: I. The effect of SV40 transformation and immortalisation on the gamma-irradiation survival of skin derived fibroblasts from normal individuals and from ataxia-telangiectasia patients and heterozygotes.
Int. J. Radiat. Biol. 54:911-928(1988)

PubMed=7836839; DOI=10.1080/09553009414551951
Jane Cole, Colin Francis Arlett;
Cloning efficiency and spontaneous mutant frequency in circulating T-lymphocytes in ataxia-telangiectasia patients.
Int. J. Radiat. Biol. 66:S123-S131(1994)

PubMed=7792600; DOI=10.1126/science.7792600
Kinneret Savitsky, Anat Bar-Shira, Shlomit Gilad, Galit Rotman, Yael Ziv, Lina Vanagaite, Danilo A. Tagle, Sara Smith, Tamar Uziel, Sharon Sfez, Maya Ashkenazi ...Show all 30 authors... , Iris Pecker, Moshe Frydman, Reli Harnik, Sankhavaram R. Patanjali, Andrew D. Simmons, Gregory A. Clines, Adam Sartiel, Richard A. Gatti, Luciana Chessa, Ozden Sanal, Martin Francis Lavin, Nicolaas G.J. Jaspers, Alexander Malcolm R. Taylor, Colin Francis Arlett, Toru Miki, Sherman Morton Weissman, Michael Lovett, Francis Sellers Collins, Yosef Shiloh; Show fewer authors
A single ataxia telangiectasia gene with a product similar to PI-3 kinase.
Science 268:1749-1753(1995)

PubMed=10987302
Pierre-Marie Girard, Nicolas Foray, Markus Stumm, Alastair P.W. Waugh, Enriqueta Riballo, Richard S. Maser, William P. Phillips, John H.J. Petrini, Colin Francis Arlett, Penelope Ann Jeggo;
Radiosensitivity in Nijmegen breakage syndrome cells is attributable to a repair defect and not cell cycle checkpoint defects.
Cancer Res. 60:4881-4888(2000)

PubMed=16714754; DOI=10.1259/bjr/83726649
Colin Francis Arlett, Piers N. Plowman, Paul Bryan Rogers, Christopher N. Parris, Fatemeh Abbaszadeh, Michael H.L. Green, Trevor J. McMillan, Cyd Bush, Nicolas Foray, Alan R. Lehmann;
Clinical and cellular ionizing radiation sensitivity in a patient with xeroderma pigmentosum.
Br. J. Radiol. 79:510-517(2006)

PubMed=18079351; DOI=10.1259/bjr/27072321
Colin Francis Arlett, Michael H.L. Green, Paul Bryan Rogers, Alan R. Lehmann, Piers N. Plowman;
Minimal ionizing radiation sensitivity in a large cohort of xeroderma pigmentosum fibroblasts.
Br. J. Radiol. 81:51-58(2008)

Cross-references
Encyclopedic resources Wikidata; Q93326315
Entry history
Entry creation06-Sep-2019
Last entry update19-Dec-2024
Version number8