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Cellosaurus BT147 [Boston] (CVCL_WW40)

[Text version]
Cell line name BT147 [Boston]
Synonyms BT 147; CPDM_1280X
Accession CVCL_WW40
Resource Identification Initiative To cite this cell line use: BT147 [Boston] (RRID:CVCL_WW40)
Comments Part of: Center for Patient Derived Models (CPDM) at Dana-Farber Cancer Institute cell line panel.
Characteristics: Low-passage-number culture.
Characteristics: Can grow as a neurosphere (PubMed=34610309).
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing; Low read coverage.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Brain, right frontal cortex; UBERON=UBERON_0001870.
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 62Y
Category Cancer cell line
Web pages Provider; CPDM; CPDM_1280X; https://docs.google.com/spreadsheets/d/1sxAPF3p6xK2h01zaiQ1ExCWwzhxeZ-oDLN3s3LeJq98/edit?usp=sharing
Publications

PubMed=24440720; DOI=10.1016/j.celrep.2013.12.032; PMCID=PMC4041390
Chudnovsky Y., Kim D., Zheng S.-Y., Whyte W.A., Bansal M., Bray M.-A., Gopal S., Theisen M.A., Bilodeau S., Thiru P., Muffat J., Yilmaz O.H., Mitalipova M., Woolard K.D., Lee J., Nishimura R., Sakata N., Fine H.A., Carpenter A.E., Silver S.J., Verhaak R.G.W., Califano A., Young R.A., Ligon K.L., Mellinghoff I.K., Root D.E., Sabatini D.M., Hahn W.C., Chheda M.G.
ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state.
Cell Rep. 6:313-324(2014)

PubMed=25184684; DOI=10.1371/journal.pone.0106694; PMCID=PMC4153667
Holmberg Olausson K., Maire C.L., Haidar S., Ling J., Learner E., Nister M., Ligon K.L.
Prominin-1 (CD133) defines both stem and non-stem cell populations in CNS development and gliomas.
PLoS ONE 9:e106694.1-e106694.11(2014)

PubMed=34610309; DOI=10.1016/j.celrep.2021.109788
Stockslager M.A., Malinowski S., Touat M., Yoon J.C., Geduldig J., Mirza M., Kim A.S., Wen P.Y.-C., Chow K.-H., Ligon K.L., Manalis S.R.
Functional drug susceptibility testing using single-cell mass predicts treatment outcome in patient-derived cancer neurosphere models.
Cell Rep. 37:109788.1-109788.12(2021)

Cross-references
Chemistry resources PharmacoDB; BT147_117_2019
Encyclopedic resources Wikidata; Q93432571
Entry history
Entry creation06-Sep-2019
Last entry update10-Apr-2025
Version number6