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Cellosaurus PA-JEB (CVCL_WW22)

[Text version]
Cell line name PA-JEB
Accession CVCL_WW22
Resource Identification Initiative To cite this cell line use: PA-JEB (RRID:CVCL_WW22)
Comments Doubling time: ~36 hours (PubMed=9660880).
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Disease Epidermolysis bullosa, junctional, with pyloric atresia (NCIt: C162474)
Junctional epidermolysis bullosa-pyloric atresia syndrome (ORDO: Orphanet_79403)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_WW23 (PA-JEB/beta4)CVCL_WW24 (PA-JEB/beta4-EGFP)
Sex of cell Sex unspecified
Age at sampling 5D
Category Transformed cell line
Publications

PubMed=8832392; DOI=10.1242/jcs.109.7.1695
Carien M. Niessen, Liesbeth M.H. van der Raaij-Helmer, Esther H.M. Hulsman, Ronald van der Neut, Marcellinus Franciscus Jonkman, Arnoud Sonnenberg;
Deficiency of the integrin beta 4 subunit in junctional epidermolysis bullosa with pyloric atresia: consequences for hemidesmosome formation and adhesion properties.
J. Cell Sci. 109:1695-1706(1996)

PubMed=9660880; DOI=10.1083/jcb.142.1.271; PMCID=PMC2133016
Roel Q.J. Schaapveld, Luca Borradori, Dirk Geerts, Manuel R. van Leusden, Ingrid Kuikman, Mirjam G. Nievers, Carien M. Niessen, Renske D.M. Steenbergen, Peter J.F. Snijders, Arnoud Sonnenberg;
Hemidesmosome formation is initiated by the beta4 integrin subunit, requires complex formation of beta4 and HD1/plectin, and involves a direct interaction between beta4 and the bullous pemphigoid antigen 180.
J. Cell Biol. 142:271-284(1998)

PubMed=10811835; DOI=10.1083/jcb.149.4.969; PMCID=PMC2174566
Lotus M.T. Sterk, Cecile Anna Wilhelmina Geuijen, Lauran C.J.M. Oomen, Jero Calafat, Hans Janssen, Arnoud Sonnenberg;
The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes.
J. Cell Biol. 149:969-982(2000)

PubMed=12429829; DOI=10.1091/mbc.02-01-0601; PMCID=PMC133597
Cecile Anna Wilhelmina Geuijen, Arnoud Sonnenberg;
Dynamics of the alpha6beta4 integrin in keratinocytes.
Mol. Biol. Cell 13:3845-3858(2002)

Cross-references
Encyclopedic resources Wikidata; Q98128425
Entry history
Entry creation06-Sep-2019
Last entry update21-Mar-2023
Version number4