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Cellosaurus NCI-H1975/OSIR (CVCL_WV99)

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Cell line name NCI-H1975/OSIR
Accession CVCL_WV99
Resource Identification Initiative To cite this cell line use: NCI-H1975/OSIR (RRID:CVCL_WV99)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_90943; Osimertinib (AZD9291).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Gly118Asp (c.353G>A); ClinVar=VCV000156446; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1511 (NCI-H1975)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=27835594; DOI=10.18632/oncotarget.13150; PMCID=PMC5348415
Zheng-Hai Tang, Xiao-Ming Jiang, Xia Guo, Chi Man Vivienne Fong, Xiu-Ping Chen, Jin-Jian Lu;
Characterization of osimertinib (AZD9291)-resistant non-small cell lung cancer NCI-H1975/OSIR cell line.
Oncotarget 7:81598-81610(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_WV99
Encyclopedic resources Wikidata; Q95993289
Entry history
Entry creation06-Sep-2019
Last entry update19-Dec-2024
Version number8