ID   NCI-H1975/OSIR
AC   CVCL_WV99
DR   cancercelllines; CVCL_WV99
DR   Wikidata; Q95993289
RX   PubMed=27835594;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:90943; Osimertinib (AZD9291).
CC   Sequence variation: Mutation; HGNC; 3236; EGFR; Simple; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Gly118Asp (c.353G>A); ClinVar=VCV000156446; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1511 ! NCI-H1975
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 06-09-19; Last updated: 05-10-23; Version: 7
//
RX   PubMed=27835594; DOI=10.18632/oncotarget.13150;
RA   Tang Z.-H., Jiang X.-M., Guo X., Fong C.M.V., Chen X.-P., Lu J.-J.;
RT   "Characterization of osimertinib (AZD9291)-resistant non-small cell
RT   lung cancer NCI-H1975/OSIR cell line.";
RL   Oncotarget 7:81598-81610(2016).
//