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Cellosaurus SJG-8 (CVCL_WV09)

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Cell line name SJG-8
Synonyms SJG-008
Accession CVCL_WV09
Resource Identification Initiative To cite this cell line use: SJG-8 (RRID:CVCL_WV09)
Comments Omics: Genomics; Whole exome sequencing.
Miscellaneous: STR profile from personal communication of Broad, Simon.
Derived from site: In situ; Oral cavity, alveolar ridge; UBERON=UBERON_0004103.
Sequence variations
  • Mutation; HGNC; HGNC:3595; FAT1; Simple; p.Thr677fs (c.2029_2036delACACCAGT); Zygosity=Unspecified (PubMed=27693639).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Asp154His (c.460G>C); Zygosity=Unspecified (PubMed=27693639).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Trp53Ter (c.159G>A); ClinVar=VCV000420659; Zygosity=Unspecified (PubMed=27693639).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Unspecified (PubMed=27693639).
Disease Alveolar ridge squamous cell carcinoma (NCIt: C170774)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 68Y
Category Cancer cell line
STR profile Source(s): Direct_author_submission

Markers:
AmelogeninX,Y
CSF1PO11,12
D3S135815,17
D5S8189,12
D7S8209
D8S117910,13
D13S31711
D16S53910,11
D18S5112,16
D21S1128,30
FGA21
Penta D8,9
Penta E7
TH019.3
TPOX8,11
vWA16

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Publications

CLPUB00518
Stephen J. Goldie;
Studies of FRMD4A in two models of squamous cell carcinoma.
Thesis PhD (2011); University of Cambridge; Cambridge; United Kingdom

PubMed=27693639; DOI=10.1016/j.canlet.2016.09.014; PMCID=PMC5090049
Tyler F. Hayes, Nathan Benaich, Stephen J. Goldie, Kalle Sipila, Ashley Ames-Draycott, Wen-Jun Cai, Guang-Liang Yin, Fiona Mary Watt;
Integrative genomic and functional analysis of human oral squamous cell carcinoma cell lines reveals synergistic effects of FAT1 and CASP8 inactivation.
Cancer Lett. 383:106-114(2016)

CLPUB00517
Ashley Jane Pritchard;
Correlating genetic change with changes in cell behaviour in squamous cell carcinoma of the head and neck (SCCHN). Focus on inactivating NOTCH1 mutations.
Thesis PhD (2018); King's College London; London; United Kingdom

Cross-references
Cell line databases/resources cancercelllines; CVCL_WV09
Encyclopedic resources Wikidata; Q98132638
Entry history
Entry creation05-Jul-2019
Last entry update10-Apr-2025
Version number12