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Cellosaurus MN7 (CVCL_WS46)

[Text version]
Cell line name MN7
Accession CVCL_WS46
Resource Identification Initiative To cite this cell line use: MN7 (RRID:CVCL_WS46)
Comments Group: Space-flown cell line (cellonaut).
Characteristics: Osteogenic stromal cell line. Can mineralize in vitro when cultured on a collagen type I matrix.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Omics: Secretome proteome analysis by 2D-DE.
Anecdotal: Have been flown in space on Cosmos-2229 (Bion-10) to study growth microgravity (CelloPub=CLPUB00511; PubMed=9813886).
Derived from site: In situ; Bone marrow, stroma; UBERON=UBERON_0007195.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: BALB/c.
Sex of cell Sex unspecified
Age at sampling 12W
Category Transformed cell line

PubMed=1571849; DOI=10.1007/BF00301635
Mathieu E., Schoeters G., Vander Plaetse F., Merregaert J.H.
Establishment of an osteogenic cell line derived from adult mouse bone marrow stroma by use of a recombinant retrovirus.
Calcif. Tissue Int. 50:362-371(1992)

Bierkens J.G.E.A., Maes J., Ooms D., Collier M., Vangenechten C., Borremans B., van Vlasselaer P., Schoeters G.
Decreased acquisition of osteoblastic phenotype markers and increased response to interleukin-1 and parathyroid hormone in pre-osteoblast like cells under microgravity.
(In) Life sciences research in space. Proceedings of the fifth European symposium held 26 September-1 October 1993 in Arcachon France, ESA SP-366; Oser H., Guyenne T.D. (eds.); pp.25-30; European Space Agency; Noordwijk (1994)

PubMed=8079665; DOI=10.1002/jbmr.5650090616
Mathieu E., Meheus L., Raymackers J., Merregaert J.H.
Characterization of the osteogenic stromal cell line MN7: identification of secreted MN7 proteins using two-dimensional polyacrylamide gel electrophoresis, western blotting, and microsequencing.
J. Bone Miner. Res. 9:903-913(1994)

Berezovskaia O.P., Rodionova N.V.
The effect of microgravity on osteogenic cells in culture Ultrastructural research.
Tistol. Genet. 32:3-8(1998)

Encyclopedic resources Wikidata; Q95990414
Entry history
Entry creation05-Jul-2019
Last entry update29-Jun-2023
Version number6