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Cellosaurus CHO-S FUT8-/- (CVCL_WJ93)

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Cell line name CHO-S FUT8-/-
Synonyms FUT8-/- CHO-S
Accession CVCL_WJ93
Resource Identification Initiative To cite this cell line use: CHO-S FUT8-/- (RRID:CVCL_WJ93)
Comments Characteristics: Useful for the production of fucose-negative antibodies.
Knockout cell: Method=CRISPR/Cas9; UniProtKB; G3HCE4; Fut8.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_7183 (CHO-S)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=32624826; DOI=10.1002/elsc.201600255; PMCID=PMC6999357
Hui-Fang Zong, Lei Han, Kai Ding, Jia-Xian Wang, Tao Sun, Xin-Yu Zhang, Cedric Cagliero, Hua Jiang, Yue-Qing Xie, Jian-Rong Xu, Bao-Hong Zhang, Jian-Wei Zhu;
Producing defucosylated antibodies with enhanced in vitro antibody-dependent cellular cytotoxicity via FUT8 knockout CHO-S cells.
Eng. Life Sci. 17:801-808(2017)

PubMed=30982137; DOI=10.1007/s00449-019-02124-7
Yuan Yuan, Hui-Fang Zong, Jing-Yi Bai, Lei Han, Lei Wang, Xin-Yu Zhang, Xiao-Shuai Zhang, Jing-Yi Zhang, Chen-Xiao Xu, Jian-Wei Zhu, Bao-Hong Zhang;
Bioprocess development of a stable FUT8(-/-)-CHO cell line to produce defucosylated anti-HER2 antibody.
Bioprocess Biosyst. Eng. 42:1263-1271(2019)

Cross-references
Encyclopedic resources Wikidata; Q93452631
Entry history
Entry creation24-May-2019
Last entry update30-Jan-2024
Version number7