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Cellosaurus OP6 (CVCL_WI57)

[Text version]
Cell line name OP6
Synonyms OP-6; Olfactory Placode 6
Accession CVCL_WI57
Resource Identification Initiative To cite this cell line use: OP6 (RRID:CVCL_WI57)
Comments Characteristics: At the permissive temperature of 33 Celsius express a transcriptional profile representing intermediate-late developmental stages in the olfactory receptor neuron (ORN) lineage. At the non-permissive temperature of 39 Celsius can be induced by all-trans retinoic acid to differentiate into a population of mature bipolar olfactory receptor neuron-like cells (CelloPub=CLPUB00748; PubMed=12093156).
Doubling time: 99 hours (Note=At 33 Celsius) (CelloPub=CLPUB00748; PubMed=12093156).
Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; SV40 large T antigen.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58).
Caution: PubMed=10630978 incorrectly describes this cell line as originating from a mouse neuroblastoma.
Derived from site: In situ; Olfactory placode; UBERON=UBERON_0003050.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C3H.
Sex of cell Sex unspecified
Age at sampling 10-11FD
Category Conditionally immortalized cell line
Publications

CLPUB00748
Boolay S.
Immortalisation, characterisation and differentiation of temperature sensitive cell lines from the olfactory neuroepithelium.
Thesis PhD (1998); University of Cape Town; Cape Town; South Africa

PubMed=10630978; DOI=10.1667/0033-7587(2000)153[0062:FORIMI]2.0.CO;2
Akudugu J.M., Slabbert J.P., Serafin A.M., Bohm L.
Frequency of radiation-induced micronuclei in neuronal cells does not correlate with clonogenic survival.
Radiat. Res. 153:62-67(2000)

PubMed=12093156; DOI=10.1006/mcne.2002.1106
Illing N., Boolay S., Siwoski J.S., Casper D., Lucero M.T., Roskams A.J.
Conditionally immortalized clonal cell lines from the mouse olfactory placode differentiate into olfactory receptor neurons.
Mol. Cell. Neurosci. 20:225-243(2002)

Cross-references
Cell line databases/resources Lonza; 1499
Anatomy/cell type resources BTO; BTO_0006224
Encyclopedic resources Wikidata; Q98128350
Entry history
Entry creation24-May-2019
Last entry update19-Dec-2024
Version number9