ID   OP6
AC   CVCL_WI57
SY   OP-6; Olfactory Placode 6
DR   BTO; BTO_0006224
DR   Lonza; 1499
DR   Wikidata; Q98128350
RX   CelloPub=CLPUB00748;
RX   PubMed=10630978;
RX   PubMed=12093156;
CC   Characteristics: At the permissive temperature of 33 Celsius express a transcriptional profile representing intermediate-late developmental stages in the olfactory receptor neuron (ORN) lineage. At the non-permissive temperature of 39 Celsius can be induced by all-trans retinoic acid to differentiate into a population of mature bipolar olfactory receptor neuron-like cells (CelloPub=CLPUB00748; PubMed=12093156).
CC   Doubling time: 99 hours (Note=At 33 Celsius) (CelloPub=CLPUB00748; PubMed=12093156).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; SV40 large T antigen.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58).
CC   Caution: PubMed=10630978 incorrectly describes this cell line as originating from a mouse neuroblastoma.
CC   Derived from site: In situ; Olfactory placode; UBERON=UBERON_0003050.
CC   Breed/subspecies: C3H.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
SX   Sex unspecified
AG   10-11FD
CA   Conditionally immortalized cell line
DT   Created: 24-05-19; Last updated: 19-12-24; Version: 9
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RX   CelloPub=CLPUB00748;
RA   Boolay S.;
RT   "Immortalisation, characterisation and differentiation of temperature
RT   sensitive cell lines from the olfactory neuroepithelium.";
RL   Thesis PhD (1998); University of Cape Town; Cape Town; South Africa.
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RX   PubMed=10630978; DOI=10.1667/0033-7587(2000)153[0062:FORIMI]2.0.CO;2;
RA   Akudugu J.M., Slabbert J.P., Serafin A.M., Bohm L.;
RT   "Frequency of radiation-induced micronuclei in neuronal cells does not
RT   correlate with clonogenic survival.";
RL   Radiat. Res. 153:62-67(2000).
//
RX   PubMed=12093156; DOI=10.1006/mcne.2002.1106;
RA   Illing N., Boolay S., Siwoski J.S., Casper D., Lucero M.T.,
RA   Roskams A.J.;
RT   "Conditionally immortalized clonal cell lines from the mouse olfactory
RT   placode differentiate into olfactory receptor neurons.";
RL   Mol. Cell. Neurosci. 20:225-243(2002).
//