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Cellosaurus MIA PaCa-2 GR300 (CVCL_WI24)

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Cell line name MIA PaCa-2 GR300
Synonyms MiaPaCa-2 GR300
Accession CVCL_WI24
Resource Identification Initiative To cite this cell line use: MIA PaCa-2 GR300 (RRID:CVCL_WI24)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_175901; Gemcitabine (Gemzar).
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Homozygous (from parent cell line).
Disease Pancreatic undifferentiated carcinoma (NCIt: C5722)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0428 (MIA PaCa-2)
Sex of cell Male
Age at sampling 65Y
Category Cancer cell line
Publications

PubMed=25485960; DOI=10.4161/15384047.2014.986967; PMCID=PMC4623403
Betty Kumiko Samulitis, Kelvin W. Pond, Erika Pond, Anne Elizabeth Cress, Hitendra Patel, Lee Wisner, Charmi Patel, Robert T. Dorr, Terry H. Landowski;
Gemcitabine resistant pancreatic cancer cell lines acquire an invasive phenotype with collateral hypersensitivity to histone deacetylase inhibitors.
Cancer Biol. Ther. 16:43-51(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_WI24
Encyclopedic resources Wikidata; Q95989682
Entry history
Entry creation24-May-2019
Last entry update19-Dec-2024
Version number10