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Cellosaurus NCI-N87 HR (CVCL_WH01)

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Cell line name NCI-N87 HR
Synonyms NCI N87 HR
Accession CVCL_WH01
Resource Identification Initiative To cite this cell line use: NCI-N87 HR (RRID:CVCL_WH01)
Comments Doubling time: 26 hours (PubMed=26919099).
Selected for resistance to: DrugBank; DB00072; Trastuzumab (Herceptin).
Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Gene deletion; HGNC; HGNC:6770; SMAD4; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3431; ERBB3; Simple; p.Thr757Lys (c.2270C>A); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Gastric tubular adenocarcinoma (NCIt: C5473)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1603 (NCI-N87)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=26919099; DOI=10.18632/oncotarget.7575; PMCID=PMC4951299
Chiara Arienti, Michele Zanoni, Sara Pignatta, Alberto Del Rio, Silvia Carloni, Michela Tebaldi, Gianluca Tedaldi, Anna Tesei;
Preclinical evidence of multiple mechanisms underlying trastuzumab resistance in gastric cancer.
Oncotarget 7:18424-18439(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_WH01
Encyclopedic resources Wikidata; Q95993868
Entry history
Entry creation24-May-2019
Last entry update19-Dec-2024
Version number9