Cellosaurus logo
expasy logo

Cellosaurus SW1573/2R250 (CVCL_WG77)

[Text version]
Cell line name SW1573/2R250
Synonyms SW-1573/2R250; 2R250
Accession CVCL_WG77
Resource Identification Initiative To cite this cell line use: SW1573/2R250 (RRID:CVCL_WG77)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; 6770; SMAD4; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser33Phe (c.98C>T); ClinVar=VCV000017583; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Lys111Glu (c.331A>G); ClinVar=VCV000376482; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11103; SMARCB1; Simple; c.362+1G>C; ClinVar=VCV000582116; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
Disease Minimally invasive lung adenocarcinoma (NCIt: C2923)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_WG71 (SW1573/2R160)
Sex of cell Female
Age at sampling 44Y
Category Cancer cell line
Publications

CLPUB00485
Kuiper C.M., Broxterman H.J., Baas F., Schuurhuis G.J., Haisma H.J., Scheffer G.L., Lankelma J., Pinedo H.M.
Drug transport variants without P-glycoprotein overexpression from a human squamous lung cancer cell line after selection with doxorubicin.
J. Cell. Pharmacol. 1:35-41(1990)

Cross-references
Cell line databases/resources cancercelllines; CVCL_WG77
Encyclopedic resources Wikidata; Q98132921
Entry history
Entry creation24-May-2019
Last entry update05-Oct-2023
Version number8