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Cellosaurus SW1573/2R160 (CVCL_WG71)

[Text version]
Cell line name SW1573/2R160
Synonyms SW-1573/2R160; 2R160
Accession CVCL_WG71
Resource Identification Initiative To cite this cell line use: SW1573/2R160 (RRID:CVCL_WG71)
Comments Population: Caucasian.
Doubling time: 30 hours (PubMed=9256160).
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; 6770; SMAD4; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser33Phe (c.98C>T); ClinVar=VCV000017583; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Lys111Glu (c.331A>G); ClinVar=VCV000376482; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11103; SMARCB1; Simple; c.362+1G>C; ClinVar=VCV000582116; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
Disease Minimally invasive lung adenocarcinoma (NCIt: C2923)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_WG76 (SW1573/2R80)
Children:
CVCL_WG77 (SW1573/2R250)
Sex of cell Female
Age at sampling 44Y
Category Cancer cell line
Publications

CLPUB00485
Kuiper C.M., Broxterman H.J., Baas F., Schuurhuis G.J., Haisma H.J., Scheffer G.L., Lankelma J., Pinedo H.M.
Drug transport variants without P-glycoprotein overexpression from a human squamous lung cancer cell line after selection with doxorubicin.
J. Cell. Pharmacol. 1:35-41(1990)

PubMed=1974823
Baas F., Jongsma A.P.M., Broxterman H.J., Arceci R.J., Housman D.E., Scheffer G.L., Riethorst A., van Groenigen M., Nieuwint A.W.M., Joenje H.
Non-P-glycoprotein mediated mechanism for multidrug resistance precedes P-glycoprotein expression during in vitro selection for doxorubicin resistance in a human lung cancer cell line.
Cancer Res. 50:5392-5398(1990)

PubMed=1353703
Nieuwint A.W.M., Baas F., Wiegant J., Joenje H.
Cytogenetic alterations associated with P-glycoprotein- and non-P-glycoprotein-mediated multidrug resistance in SW-1573 human lung tumor cell lines.
Cancer Res. 52:4361-4371(1992)

PubMed=9256160; DOI=10.1016/S0006-2952(97)82448-3
van Triest B., Pinedo H.M., Telleman F., van der Wilt C.L., Jansen G., Peters G.J.
Cross-resistance to antifolates in multidrug resistant cell lines with P-glycoprotein or multidrug resistance protein expression.
Biochem. Pharmacol. 53:1855-1866(1997)

Cross-references
Cell line databases/resources cancercelllines; CVCL_WG71
Encyclopedic resources Wikidata; Q98132920
Entry history
Entry creation24-May-2019
Last entry update05-Oct-2023
Version number8