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Cellosaurus PK4A sg-PRODH1_clone3 (CVCL_WB22)

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Cell line name PK4A sg-PRODH1_clone3
Synonyms sg-PRODH1_clone3
Accession CVCL_WB22
Resource Identification Initiative To cite this cell line use: PK4A sg-PRODH1_clone3 (RRID:CVCL_WB22)
Comments Knockout cell: Method=CRISPR/Cas9; MGI; MGI:97770; Prodh.
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Breed/subspecies: Pdx1-Cre;Ink4a/Arffl/fl;LSL-KrasG12D transgenic.
Sequence variations
  • Mutation; MGI; MGI:96680; Kras; Simple; p.Gly12Asp (c.35G>A); Zygosity=Unspecified (from inference of genetic background of transgenic mouse used).
Disease Mouse pancreatic ductal adenocarcinoma (NCIt: C34041)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Hierarchy Parent: CVCL_WB21 (PK4A)
Sex of cell Male
Category Cancer cell line
Publications

PubMed=28685754; DOI=10.1038/ncomms16031; PMCID=PMC5504351
Orianne Olivares, Jared R. Mayers, Victoire Gouirand, Margaret E. Torrence, Tristan Gicquel, Laurence Borge, Sophie Lac, Julie Roques, Marie-Noelle Lavaut, Patrice Berthezene, Marion Rubis ...Show all 20 authors... , Veronique Secq, Stephane Garcia, Vincent Moutardier, Dominique Lombardo, Juan Lucio Iovanna, Richard Tomasini, Fabienne Guillaumond, Matthew George Vander Heiden, Sophie Vasseur; Show fewer authors
Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions.
Nat. Commun. 8:16031.1-16031.14(2017)

Cross-references
Encyclopedic resources Wikidata; Q98128606
Entry history
Entry creation24-May-2019
Last entry update14-Aug-2025
Version number6