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Cellosaurus PK4A (CVCL_WB21)

[Text version]
Cell line name PK4A
Accession CVCL_WB21
Resource Identification Initiative To cite this cell line use: PK4A (RRID:CVCL_WB21)
Comments Doubling time: ~24 hours (Direct_author_submission).
Miscellaneous: Doubling time and sex of donor from personal communication of Gouirand, Victoire.
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Breed/subspecies: Pdx1-Cre;Ink4a/Arffl/fl;LSL-KrasG12D transgenic.
Sequence variations
  • Mutation; MGI; MGI:96680; Kras; Simple; p.Gly12Asp (c.35G>A); Zygosity=Unspecified (from inference of genetic background of transgenic mouse used).
Disease Mouse pancreatic ductal adenocarcinoma (NCIt: C34041)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Hierarchy Children:
CVCL_WB22 (PK4A sg-PRODH1_clone3)CVCL_WB23 (PK4A sg-PRODH1_clone9)
Sex of cell Male
Category Cancer cell line
Publications

PubMed=23407165; DOI=10.1073/pnas.1219555110; PMCID=PMC3593894
Fabienne Guillaumond, Julie Leca, Orianne Olivares, Marie-Noelle Lavaut, Nicolas Vidal, Patrice Berthezene, Nelson Javier Dusetti, Celine Loncle, Ezequiel Calvo, Olivier Turrini, Juan Lucio Iovanna ...Show all 13 authors... , Richard Tomasini, Sophie Vasseur; Show fewer authors
Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma.
Proc. Natl. Acad. Sci. U.S.A. 110:3919-3924(2013)

PubMed=25675507; DOI=10.1073/pnas.1421601112; PMCID=PMC4345573
Fabienne Guillaumond, Ghislain Bidaut, Mehdi Ouaissi, Stephane Servais, Victoire Gouirand, Orianne Olivares, Sophie Lac, Laurence Borge, Julie Roques, Odile Gayet, Michelle Pinault ...Show all 22 authors... , Cyrille Guimaraes, Jeremy Nigri, Celine Loncle, Marie-Noelle Lavaut, Stephane Garcia, Anne Tailleux, Bart Staels, Ezequiel Calvo, Richard Tomasini, Juan Lucio Iovanna, Sophie Vasseur; Show fewer authors
Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma.
Proc. Natl. Acad. Sci. U.S.A. 112:2473-2478(2015)

PubMed=28685754; DOI=10.1038/ncomms16031; PMCID=PMC5504351
Orianne Olivares, Jared R. Mayers, Victoire Gouirand, Margaret E. Torrence, Tristan Gicquel, Laurence Borge, Sophie Lac, Julie Roques, Marie-Noelle Lavaut, Patrice Berthezene, Marion Rubis ...Show all 20 authors... , Veronique Secq, Stephane Garcia, Vincent Moutardier, Dominique Lombardo, Juan Lucio Iovanna, Richard Tomasini, Fabienne Guillaumond, Matthew George Vander Heiden, Sophie Vasseur; Show fewer authors
Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions.
Nat. Commun. 8:16031.1-16031.14(2017)

Cross-references
Encyclopedic resources Wikidata; Q98128605
Entry history
Entry creation24-May-2019
Last entry update14-Aug-2025
Version number8