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Cellosaurus Akuba (CVCL_W933)

[Text version]
Cell line name Akuba
Synonyms AKUBA; AKUA; AK 778; AK778
Accession CVCL_W933
Secondary accession CVCL_W745
Resource Identification Initiative To cite this cell line use: Akuba (RRID:CVCL_W933)
Comments Population: African; Kenyan.
Doubling time: 21 hours (PubMed=8402660).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Cell type: B-cell; CL=CL_0000236.
Sequence variations
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=4122458; DOI=10.1002/ijc.2910100108
George Klein, Laszlo Dombos, Balwant Gothoskar;
Sensitivity of Epstein-Barr virus (EBV) producer and non-producer human lymphoblastoid cell lines to superinfection with EB-virus.
Int. J. Cancer 10:44-57(1972)

PubMed=4364259; DOI=10.1002/ijc.2910110210
George Klein, Laszlo Dombos;
Relationship between the sensitivity of EBV-carrying lymphoblastoid lines to superinfection and the inducibility of the resident viral genome.
Int. J. Cancer 11:327-337(1973)

PubMed=170370; DOI=10.1099/0022-1317-28-2-207
Alice Adams, Hans Strander, Kari Cantell;
Sensitivity of the Epstein-Barr virus transformed human lymphoid cell lines to interferon.
J. Gen. Virol. 28:207-217(1975)

PubMed=7316467; DOI=10.1111/j.1469-1809.1980.tb00953.x
Susan Povey, Stephen Jeremiah, Elizabeth Arthur, Michael Steel, George Klein;
Differences in genetic stability between human cell lines from patients with and without lymphoreticular malignancy.
Ann. Hum. Genet. 44:119-133(1980)

PubMed=6286763; DOI=10.4049/jimmunol.129.3.1336
David Benjamin, Ian Trevor Magrath, Robert T. Maguire, Carol Janus, Heather D. Todd-Kulikowsk, Robert G. Parsons;
Immunoglobulin secretion by cell lines derived from African and American undifferentiated lymphomas of Burkitt's and non-Burkitt's type.
J. Immunol. 129:1336-1342(1982)

PubMed=3080238
Hauke Sieverts, Oliver Alabaster, Walter Goldschmidts, Ian Trevor Magrath;
Expression of surface antigens during the cell cycle in different growth phases of American and African Burkitt's lymphoma cell lines.
Cancer Res. 46:1182-1188(1986)

PubMed=3100061; DOI=10.1016/0008-8749(86)90099-7
David Benjamin, Leonard S. Bazar, Brett Wallace, Robert J. Jacobson;
Heterogeneity of B-cell growth factor receptor reactivity in healthy donors and in patients with chronic lymphatic leukemia: relationship to B-cell-derived lymphokines.
Cell. Immunol. 103:394-408(1986)

PubMed=3026973; DOI=10.1002/ijc.2910390215
Barbro Ehlin-Henriksson, Agneta Manneborg-Sandlund, George Klein;
Expression of B-cell-specific markers in different Burkitt lymphoma subgroups.
Int. J. Cancer 39:211-218(1987)

PubMed=1325212; DOI=10.1182/blood.V80.5.1289.1289
David Benjamin, Thomas J. Knobloch, Mark A. Dayton;
Human B-cell interleukin-10: B-cell lines derived from patients with acquired immunodeficiency syndrome and Burkitt's lymphoma constitutively secrete large quantities of interleukin-10.
Blood 80:1289-1298(1992)

PubMed=8220424; DOI=10.1038/ng0993-56
Kishor G. Bhatia, Konrad Huppi, Gordon Spangler, David Siwarski, Radhika Iyer, Ian Trevor Magrath;
Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas.
Nat. Genet. 5:56-61(1993)

PubMed=8402660
Patrick M. O'Connor, Joany Jackman, Daniel Jondle, Kishor G. Bhatia, Ian Trevor Magrath, Kurt W. Kohn;
Role of the p53 tumor suppressor gene in cell cycle arrest and radiosensitivity of Burkitt's lymphoma cell lines.
Cancer Res. 53:4776-4780(1993)

PubMed=8515068; DOI=10.4049/jimmunol.150.12.5418
Vinay K. Jain, Jean-Gabriel Judde, Edward E. Max, Ian Trevor Magrath;
Variable IgH chain enhancer activity in Burkitt's lymphomas suggests an additional, direct mechanism of c-myc deregulation.
J. Immunol. 150:5418-5428(1993)

PubMed=7519050; DOI=10.1002/gcc.2870090408
Reinhard Zeidler, Stefan Joos, Henri-Jacques Delecluse, Hans-Gustav Klobeck, Michele Vuillaume, Gilbert Marcel Lenoir, Georg-Wilhelm Bornkamm, Martin Lipp;
Breakpoints of Burkitt's lymphoma t(8;22) translocations map within a distance of 300 kb downstream of MYC.
Genes Chromosomes Cancer 9:282-287(1994)

PubMed=8176200; DOI=10.4049/jimmunol.152.10.4749
David Benjamin, Venkatanarayanan Sharma, Thomas J. Knobloch, Richard J. Armitage, Mark A. Dayton, Raymond G. Goodwin;
B cell IL-7. Human B cell lines constitutively secrete IL-7 and express IL-7 receptors.
J. Immunol. 152:4749-4757(1994)

PubMed=7757991
Insoo Bae, Sai-Jun Fan, Kishor G. Bhatia, Kurt W. Kohn, Albert J. Fornace Jr., Patrick M. O'Connor;
Relationships between G1 arrest and stability of the p53 and p21Cip1/Waf1 proteins following gamma-irradiation of human lymphoma cells.
Cancer Res. 55:2387-2393(1995)

PubMed=8568269; DOI=10.4049/jimmunol.156.4.1626
David Benjamin, Venkatanarayanan Sharma, Marek Kubin, Jared L. Klein, Alexandrina Sartori, Jane Holliday, Giorgio Trinchieri;
IL-12 expression in AIDS-related lymphoma B cell lines.
J. Immunol. 156:1626-1637(1996)

PubMed=9473234; DOI=10.1182/blood.V91.5.1680
Ulf Klangby, Ismail Okan, Kristinn Petur Magnusson, Martin Wendland, Peter Lind, Klas G. Wiman;
p16/INK4a and p15/INK4b gene methylation and absence of p16/INK4a mRNA and protein expression in Burkitt's lymphoma.
Blood 91:1680-1687(1998)

PubMed=24590883; DOI=10.1002/gcc.22161
Eva-Maria Murga Penas, Georgia Schilling, Petra Behrmann, Marianne Klokow, Eik Vettorazzi, Carsten Bokemeyer, Judith Dierlamm;
Comprehensive cytogenetic and molecular cytogenetic analysis of 44 Burkitt lymphoma cell lines: secondary chromosomal changes characterization, karyotypic evolution, and comparison with primary samples.
Genes Chromosomes Cancer 53:497-515(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_W933
Encyclopedic resources Wikidata; Q54749033
Polymorphism and mutation databases Cosmic; 931113
Cosmic; 2808221
IARC_TP53; 7394
Entry history
Entry creation17-Jul-2014
Last entry update14-Aug-2025
Version number17