ID   Akuba
AC   CVCL_W933
AS   CVCL_W745
SY   AKUBA; AKUA; AK 778; AK778
DR   cancercelllines; CVCL_W933
DR   Cosmic; 931113
DR   Cosmic; 2808221
DR   IARC_TP53; 7394
DR   Wikidata; Q54749033
DR   Wikidata; Q54749125
RX   PubMed=170370;
RX   PubMed=1325212;
RX   PubMed=3026973;
RX   PubMed=3080238;
RX   PubMed=3100061;
RX   PubMed=4122458;
RX   PubMed=4364259;
RX   PubMed=6286763;
RX   PubMed=7316467;
RX   PubMed=7519050;
RX   PubMed=7757991;
RX   PubMed=8176200;
RX   PubMed=8220424;
RX   PubMed=8402660;
RX   PubMed=8515068;
RX   PubMed=8568269;
RX   PubMed=9473234;
RX   PubMed=24590883;
CC   Population: African; Kenyan.
CC   Doubling time: 21 hours (PubMed=8402660).
CC   Sequence variation: Gene fusion; HGNC; HGNC:5853; IGL + HGNC; HGNC:7553; MYC; Name(s)=MYC-IGL (PubMed=7519050).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (PubMed=7757991; PubMed=8402660).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Cell type: B-cell; CL=CL_0000236.
DI   NCIt; C27694; EBV-related Burkitt lymphoma
DI   ORDO; Orphanet_543; Burkitt lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 17-07-14; Last updated: 10-04-25; Version: 16
//
RX   PubMed=170370; DOI=10.1099/0022-1317-28-2-207;
RA   Adams A., Strander H., Cantell K.;
RT   "Sensitivity of the Epstein-Barr virus transformed human lymphoid cell
RT   lines to interferon.";
RL   J. Gen. Virol. 28:207-217(1975).
//
RX   PubMed=1325212; DOI=10.1182/blood.V80.5.1289.1289;
RA   Benjamin D., Knobloch T.J., Dayton M.A.;
RT   "Human B-cell interleukin-10: B-cell lines derived from patients with
RT   acquired immunodeficiency syndrome and Burkitt's lymphoma
RT   constitutively secrete large quantities of interleukin-10.";
RL   Blood 80:1289-1298(1992).
//
RX   PubMed=3026973; DOI=10.1002/ijc.2910390215;
RA   Ehlin-Henriksson B., Manneborg-Sandlund A., Klein G.;
RT   "Expression of B-cell-specific markers in different Burkitt lymphoma
RT   subgroups.";
RL   Int. J. Cancer 39:211-218(1987).
//
RX   PubMed=3080238;
RA   Sieverts H., Alabaster O., Goldschmidts W., Magrath I.T.;
RT   "Expression of surface antigens during the cell cycle in different
RT   growth phases of American and African Burkitt's lymphoma cell lines.";
RL   Cancer Res. 46:1182-1188(1986).
//
RX   PubMed=3100061; DOI=10.1016/0008-8749(86)90099-7;
RA   Benjamin D., Bazar L.S., Wallace B., Jacobson R.J.;
RT   "Heterogeneity of B-cell growth factor receptor reactivity in healthy
RT   donors and in patients with chronic lymphatic leukemia: relationship
RT   to B-cell-derived lymphokines.";
RL   Cell. Immunol. 103:394-408(1986).
//
RX   PubMed=4122458; DOI=10.1002/ijc.2910100108;
RA   Klein G., Dombos L., Gothoskar B.;
RT   "Sensitivity of Epstein-Barr virus (EBV) producer and non-producer
RT   human lymphoblastoid cell lines to superinfection with EB-virus.";
RL   Int. J. Cancer 10:44-57(1972).
//
RX   PubMed=4364259; DOI=10.1002/ijc.2910110210;
RA   Klein G., Dombos L.;
RT   "Relationship between the sensitivity of EBV-carrying lymphoblastoid
RT   lines to superinfection and the inducibility of the resident viral
RT   genome.";
RL   Int. J. Cancer 11:327-337(1973).
//
RX   PubMed=6286763; DOI=10.4049/jimmunol.129.3.1336;
RA   Benjamin D., Magrath I.T., Maguire R.T., Janus C., Todd-Kulikowsk H.D.,
RA   Parsons R.G.;
RT   "Immunoglobulin secretion by cell lines derived from African and
RT   American undifferentiated lymphomas of Burkitt's and non-Burkitt's
RT   type.";
RL   J. Immunol. 129:1336-1342(1982).
//
RX   PubMed=7316467; DOI=10.1111/j.1469-1809.1980.tb00953.x;
RA   Povey S., Jeremiah S., Arthur E., Steel M., Klein G.;
RT   "Differences in genetic stability between human cell lines from
RT   patients with and without lymphoreticular malignancy.";
RL   Ann. Hum. Genet. 44:119-133(1980).
//
RX   PubMed=7519050; DOI=10.1002/gcc.2870090408;
RA   Zeidler R., Joos S., Delecluse H.-J., Klobeck H.-G., Vuillaume M.,
RA   Lenoir G.M., Bornkamm G.-W., Lipp M.;
RT   "Breakpoints of Burkitt's lymphoma t(8;22) translocations map within a
RT   distance of 300 kb downstream of MYC.";
RL   Genes Chromosomes Cancer 9:282-287(1994).
//
RX   PubMed=7757991;
RA   Bae I., Fan S.-J., Bhatia K.G., Kohn K.W., Fornace A.J. Jr.,
RA   O'Connor P.M.;
RT   "Relationships between G1 arrest and stability of the p53 and
RT   p21Cip1/Waf1 proteins following gamma-irradiation of human lymphoma
RT   cells.";
RL   Cancer Res. 55:2387-2393(1995).
//
RX   PubMed=8176200; DOI=10.4049/jimmunol.152.10.4749;
RA   Benjamin D., Sharma V., Knobloch T.J., Armitage R.J., Dayton M.A.,
RA   Goodwin R.G.;
RT   "B cell IL-7. Human B cell lines constitutively secrete IL-7 and
RT   express IL-7 receptors.";
RL   J. Immunol. 152:4749-4757(1994).
//
RX   PubMed=8220424; DOI=10.1038/ng0993-56;
RA   Bhatia K.G., Huppi K., Spangler G., Siwarski D., Iyer R., Magrath I.T.;
RT   "Point mutations in the c-Myc transactivation domain are common in
RT   Burkitt's lymphoma and mouse plasmacytomas.";
RL   Nat. Genet. 5:56-61(1993).
//
RX   PubMed=8402660;
RA   O'Connor P.M., Jackman J., Jondle D., Bhatia K.G., Magrath I.T.,
RA   Kohn K.W.;
RT   "Role of the p53 tumor suppressor gene in cell cycle arrest and
RT   radiosensitivity of Burkitt's lymphoma cell lines.";
RL   Cancer Res. 53:4776-4780(1993).
//
RX   PubMed=8515068; DOI=10.4049/jimmunol.150.12.5418;
RA   Jain V.K., Judde J.-G., Max E.E., Magrath I.T.;
RT   "Variable IgH chain enhancer activity in Burkitt's lymphomas suggests
RT   an additional, direct mechanism of c-myc deregulation.";
RL   J. Immunol. 150:5418-5428(1993).
//
RX   PubMed=8568269; DOI=10.4049/jimmunol.156.4.1626;
RA   Benjamin D., Sharma V., Kubin M., Klein J.L., Sartori A., Holliday J.,
RA   Trinchieri G.;
RT   "IL-12 expression in AIDS-related lymphoma B cell lines.";
RL   J. Immunol. 156:1626-1637(1996).
//
RX   PubMed=9473234; DOI=10.1182/blood.V91.5.1680;
RA   Klangby U., Okan I., Magnusson K.P., Wendland M., Lind P., Wiman K.G.;
RT   "p16/INK4a and p15/INK4b gene methylation and absence of p16/INK4a
RT   mRNA and protein expression in Burkitt's lymphoma.";
RL   Blood 91:1680-1687(1998).
//
RX   PubMed=24590883; DOI=10.1002/gcc.22161;
RA   Murga Penas E.-M., Schilling G., Behrmann P., Klokow M.,
RA   Vettorazzi E., Bokemeyer C., Dierlamm J.;
RT   "Comprehensive cytogenetic and molecular cytogenetic analysis of 44
RT   Burkitt lymphoma cell lines: secondary chromosomal changes
RT   characterization, karyotypic evolution, and comparison with primary
RT   samples.";
RL   Genes Chromosomes Cancer 53:497-515(2014).
//