| Cell line name |
KY-VCR |
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| Accession |
CVCL_W295 |
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| Resource Identification Initiative |
To cite this cell line use: KY-VCR (RRID:CVCL_W295) |
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| Comments |
Population: Japanese.
Selected for resistance to: ChEBI; CHEBI_28445; Vincristine (VCR).
Derived from site: In situ; Brain, meninges; UBERON=UBERON_0010743. |
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| Sequence variations |
- Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61His (c.183A>C); ClinVar=VCV000375871; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Adult acute myelomonocytic leukemia (NCIt: C7962)
Acute myelomonocytic leukemia (ORDO: Orphanet_517) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_1346 (KY821) |
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| Sex of cell |
Male |
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| Age at sampling |
28Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=1472928; DOI=10.3109/10428199209053617
Toshio Kakihara, Toshiyuki Yamada, Takeaki Fukuda, Yoshihisa Ohnishi, Kenji Kishi, Akira Shibata;
Vincristine-resistant human leukemia cell line: new monoclonal antibodies to a 65kDa membrane protein.
Leuk. Lymphoma 7:157-164(1992) PubMed=8387619; DOI=10.1016/0145-2126(93)90019-H
Takeaki Fukuda, Toshio Kakihara, Tomoko Kamishima, Yoshihisa Ohnishi, Makoto Naito, Kenji Kishi, Akira Shibata;
Different effects of various hematopoietic growth factors on myelomonocytic cell line (KY-821) and its drug-resistant sublines.
Leuk. Res. 17:325-332(1993) PubMed=12716468; DOI=10.1111/j.1349-7006.2002.tb01336.x; PMCID=PMC5927113
Hajime Shimizu, Takeaki Fukuda, Mohammad Ghazizadeh, Mikio Nagashima, Oichi Kawanami, Toshimitsu Suzuki;
Molecular cytogenetic characterization of drug-resistant leukemia cell lines by comparative genomic hybridization and fluorescence in situ hybridization.
Jpn. J. Cancer Res. 93:902-910(2002) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_W295
|
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| Encyclopedic resources |
Wikidata; Q54900773
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| Entry history |
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| Entry creation | 16-Apr-2014 |
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| Last entry update | 14-Aug-2025 |
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| Version number | 16 |
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