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Cellosaurus KY-MTX (CVCL_W293)

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Cell line name KY-MTX
Synonyms KY821/MTX
Accession CVCL_W293
Resource Identification Initiative To cite this cell line use: KY-MTX (RRID:CVCL_W293)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI_44185; Methotrexate (MTX).
Derived from site: In situ; Brain, meninges; UBERON=UBERON_0010743.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61His (c.183A>C); ClinVar=VCV000375871; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (from parent cell line).
Disease Adult acute myelomonocytic leukemia (NCIt: C7962)
Acute myelomonocytic leukemia (ORDO: Orphanet_517)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1346 (KY821)
Sex of cell Male
Age at sampling 28Y
Category Cancer cell line
Publications

PubMed=1560671; DOI=10.1016/0145-2126(92)90059-G
Hiroyuki Saito, Kenji Kishi, Miwako Narita, Tatsuo Furukawa, Ei-ichi Nagura, Taira Maekawa, Tatsuo Abe, Akira Shibata;
A new myeloblastic leukemia cell line with double minute chromosomes Induction of methotrexate resistance and dihydrofolate reductase gene amplification.
Leuk. Res. 16:217-226(1992)

PubMed=8387619; DOI=10.1016/0145-2126(93)90019-H
Takeaki Fukuda, Toshio Kakihara, Tomoko Kamishima, Yoshihisa Ohnishi, Makoto Naito, Kenji Kishi, Akira Shibata;
Different effects of various hematopoietic growth factors on myelomonocytic cell line (KY-821) and its drug-resistant sublines.
Leuk. Res. 17:325-332(1993)

Cross-references
Cell line databases/resources cancercelllines; CVCL_W293
Encyclopedic resources Wikidata; Q54900770
Entry history
Entry creation16-Apr-2014
Last entry update14-Aug-2025
Version number15