| Cell line name |
KM12-L4A |
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| Synonyms |
Km 12 L4A; KM12L4-A; KM12L4A; KM12L4a |
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| Accession |
CVCL_W220 |
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| Resource Identification Initiative |
To cite this cell line use: KM12-L4A (RRID:CVCL_W220) |
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| Comments |
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-12496.
Registration: Chiron Master Culture Collection; CMCC 11606 (CMCC #11606).
Population: Caucasian.
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
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| Sequence variations |
- Gene fusion; HGNC; HGNC:8031; NTRK1 + HGNC; HGNC:12012; TPM3; Name(s)=TPM3-NTRK1 (from parent cell line).
- Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:583; APC; Simple; p.Asn1819fs*7 (c.5454_5455insA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Asn1784Hisfs*7 (c.5350_5351delAA); ClinVar=VCV000037959; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gly129Ter (c.385G>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val73Trpfs*50 (c.216delC) (p.P72fs); ClinVar=VCV000428897; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.His179Arg (c.536A>G); ClinVar=VCV000376606; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Colon carcinoma (NCIt: C4910) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_5946 (KM12-L4) |
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| Sex of cell |
Male |
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| Age at sampling |
Age unspecified |
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| Category |
Cancer cell line |
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| Publications | PubMed=3349467
Morikawa K., Walker S.M., Jessup J.M., Fidler I.J.
In vivo selection of highly metastatic cells from surgical specimens of different primary human colon carcinomas implanted into nude mice.
Cancer Res. 48:1943-1948(1988) PubMed=15170669; DOI=10.1002/ijc.20195
Camps J., Morales C., Prat E., Ribas M., Capella G., Egozcue J., Peinado M.A., Miro R.
Genetic evolution in colon cancer KM12 cells and metastatic derivates.
Int. J. Cancer 110:869-874(2004) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_W220
|
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| Encyclopedic resources |
Wikidata; Q54900058
|
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| Entry history |
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| Entry creation | 16-Apr-2014 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 18 |
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