Cell line name |
KM12-L4A |
Synonyms |
Km 12 L4A; KM12L4-A; KM12L4A; KM12L4a |
Accession |
CVCL_W220 |
Resource Identification Initiative |
To cite this cell line use: KM12-L4A (RRID:CVCL_W220) |
Comments |
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-12496. Registration: Chiron Master Culture Collection; CMCC 11606 (CMCC #11606). Population: Caucasian. Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
Sequence variations |
- Gene fusion; HGNC; HGNC:8031; NTRK1 + HGNC; HGNC:12012; TPM3; Name(s)=TPM3-NTRK1 (from parent cell line).
- Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:583; APC; Simple; p.Asn1819fs*7 (c.5454_5455insA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Asn1784Hisfs*7 (c.5350_5351delAA); ClinVar=VCV000037959; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gly129Ter (c.385G>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val73Trpfs*50 (c.216delC) (p.P72fs); ClinVar=VCV000428897; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.His179Arg (c.536A>G); ClinVar=VCV000376606; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Colon carcinoma (NCIt: C4910) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_5946 (KM12-L4) |
Sex of cell |
Male |
Age at sampling |
Age unspecified |
Category |
Cancer cell line |
Publications | PubMed=3349467 Kiyoshi Morikawa, Shirley M. Walker, John Milburn Jessup, Isaiah Joshua Fidler; In vivo selection of highly metastatic cells from surgical specimens of different primary human colon carcinomas implanted into nude mice. Cancer Res. 48:1943-1948(1988) PubMed=15170669; DOI=10.1002/ijc.20195 Jordi Camps, Cristina Morales, Esther Prat, Maria Ribas, Gabriel Capella, Josep Egozcue, Miguel Angel Peinado, Rosa Miro; Genetic evolution in colon cancer KM12 cells and metastatic derivates. Int. J. Cancer 110:869-874(2004) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_W220
|
Encyclopedic resources |
Wikidata; Q54900058
|
Entry history |
Entry creation | 16-Apr-2014 |
Last entry update | 19-Dec-2024 |
Version number | 18 |
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