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Cellosaurus A549-Taxol (CVCL_W218)

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Cell line name A549-Taxol
Synonyms A549/Taxol
Accession CVCL_W218
Resource Identification Initiative To cite this cell line use: A549-Taxol (RRID:CVCL_W218)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_45863; Paclitaxel (Taxol).
Omics: Proteomics; 2DE-MS.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0023 (A-549)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=20499251; DOI=10.1007/s00432-010-0913-9
Qiang-Ling Sun, Hui-Fang Sha, Xiao-Hua Yang, Guo-Lian Bao, Jing Lu, Yin-Yin Xie;
Comparative proteomic analysis of paclitaxel sensitive A549 lung adenocarcinoma cell line and its resistant counterpart A549-Taxol.
J. Cancer Res. Clin. Oncol. 137:521-532(2011)

PubMed=22460125; DOI=10.2119/molmed.2011.00230; PMCID=PMC3409275
Rui Wang, Jia-Yuan Huang, Bing Feng, Wei De, Long-Bang Chen;
Identification of ING4 (inhibitor of growth 4) as a modulator of docetaxel sensitivity in human lung adenocarcinoma.
Mol. Med. 18:874-886(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_W218
Encyclopedic resources Wikidata; Q54607041
Entry history
Entry creation16-Apr-2014
Last entry update10-Apr-2025
Version number15