ID   A549-Taxol
AC   CVCL_W218
SY   A549/Taxol
DR   cancercelllines; CVCL_W218
DR   Wikidata; Q54607041
RX   PubMed=20499251;
RX   PubMed=22460125;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:45863; Paclitaxel (Taxol).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
CC   Omics: Proteome analysis by 2D-DE/MS.
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0023 ! A-549
SX   Male
AG   58Y
CA   Cancer cell line
DT   Created: 16-04-14; Last updated: 05-10-23; Version: 13
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RX   PubMed=20499251; DOI=10.1007/s00432-010-0913-9;
RA   Sun Q.-L., Sha H.-F., Yang X.-H., Bao G.-L., Lu J., Xie Y.-Y.;
RT   "Comparative proteomic analysis of paclitaxel sensitive A549 lung
RT   adenocarcinoma cell line and its resistant counterpart A549-Taxol.";
RL   J. Cancer Res. Clin. Oncol. 137:521-532(2011).
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RX   PubMed=22460125; DOI=10.2119/molmed.2011.00230;
RA   Wang R., Huang J.-Y., Feng B., De W., Chen L.-B.;
RT   "Identification of ING4 (inhibitor of growth 4) as a modulator of
RT   docetaxel sensitivity in human lung adenocarcinoma.";
RL   Mol. Med. 18:874-886(2012).
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