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Cellosaurus HSJD-DIPG-007 (CVCL_VU70)

[Text version]
Cell line name HSJD-DIPG-007
Synonyms HSJD-DIPG007; DIPG007; Hospital Sant Joan de Deu-Diffuse Intrinsic Pontine Glioma-007
Accession CVCL_VU70
Resource Identification Initiative To cite this cell line use: HSJD-DIPG-007 (RRID:CVCL_VU70)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Omics: Genomics; ChIP-seq; H3K27ac.
Omics: Genomics; ChIP-seq; H3K27me3.
Omics: Genomics; Chromosome conformation analysis; Hi-C.
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Brainstem, pons; UBERON=UBERON_0000988.
Sequence variations
Disease Diffuse intrinsic pontine glioma (NCIt: C94764)
Diffuse intrinsic pontine glioma (ORDO: Orphanet_497188)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_C1MT (HSJD-DIPG-007-NTC)CVCL_C1MU (HSJD-DIPG-007-TP53 KO)
Sex of cell Male
Age at sampling 6Y
Category Cancer cell line
STR profile Source(s): PubMed=34732238

Markers:
AmelogeninX,Y
CSF1PO10
D5S81813
D7S8209,12
D13S31713
D16S53913,14
D21S1129,30
TH016,9.3
TPOX8
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=25628092; DOI=10.1038/bjc.2015.16; PMCID=PMC4333505
Julia V. Cockle, Susan Picton, Jane Levesley, Elizabeth Jane Ilett, Angel Montero Carcaboso, Susan Short, L.P. Steel, Alan Melcher, Sean E. Lawler, Anke Bruning-Richardson;
Cell migration in paediatric glioma; characterisation and potential therapeutic targeting.
Br. J. Cancer 112:693-703(2015)

PubMed=27325687; DOI=10.1158/1535-7163.MCT-15-0558
Marc H.A. Jansen, Tonny Lagerweij, A. Charlotte P. Sewing, Danielle J. Vugts, Dannis G. van Vuurden, Carla F.M. Molthoff, Viola Caretti, Susanna J.E. Veringa, Naomi Petersen, Angel Montero Carcaboso, David Pieter Noske ...Show all 16 authors... , William Peter Vandertop, Pieter Wesseling, Guus A.M.S. van Dongen, Gertjan J.L. Kaspers, Esther Hulleman; Show fewer authors
Bevacizumab targeting diffuse intrinsic pontine glioma: results of 89Zr-bevacizumab PET imaging in brain tumor models.
Mol. Cancer Ther. 15:2166-2174(2016)

PubMed=28947132; DOI=10.1016/j.yexcr.2017.09.032
Michael Hananja Meel, A. Charlotte P. Sewing, Piotr Waranecki, Dennis S. Metselaar, Laurine E. Wedekind, Jan Koster, Dannis G. van Vuurden, Gertjan J.L. Kaspers, Esther Hulleman;
Culture methods of diffuse intrinsic pontine glioma cells determine response to targeted therapies.
Exp. Cell Res. 360:397-403(2017)

PubMed=31439867; DOI=10.1038/s41467-019-11732-6; PMCID=PMC6706443
Nathan R. Fons, Ranjini K. Sundaram, Gregory A. Breuer, Sen Peng, Ryan L. McLean, Aravind N. Kalathil, Mark S. Schmidt, Diana M. Carvalho, Alan Mackay, Chris Jones, Angel Montero Carcaboso ...Show all 15 authors... , Javad Nazarian, Michael E. Berens, Charles Brenner, Ranjit S. Bindra; Show fewer authors
PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma.
Nat. Commun. 10:3790.1-3790.10(2019)

PubMed=32229503; DOI=10.1158/1541-7786.MCR-19-0507
Zhao-Hui Wang, Cheng Xu, Bill H. Diplas, Casey Joseph Moure, Chin-Pu Jason Chen, Lee H. Chen, Chang-Zheng Du, Hui-Shan Zhu, Paula K. Greer, Li-Wei Zhang, Yi-Ping He ...Show all 13 authors... , Matthew S. Waitkus, Hai Yan; Show fewer authors
Targeting mutant PPM1D sensitizes diffuse intrinsic pontine glioma cells to the PARP inhibitor olaparib.
Mol. Cancer Res. 18:968-980(2020)

PubMed=34078608; DOI=10.1126/sciadv.abg4126; PMCID=PMC10166578
Juan Wang, Tina Yi-Ting Huang, Ye Hou, Elizabeth Thomas Bartom, Xin-Yan Lu, Ali Shilatifard, Feng Yue, Amanda Muhs Saratsis;
Epigenomic landscape and 3D genome structure in pediatric high-grade glioma.
Sci. Adv. 7:eabg4126.1-eabg4126.16(2021)

PubMed=34732238; DOI=10.1186/s40478-021-01270-y; PMCID=PMC8565061
Cheng Xu, Heng Liu, Christopher J. Pirozzi, Lee H. Chen, Paula K. Greer, Bill H. Diplas, Li-Wei Zhang, Matthew S. Waitkus, Yi-Ping He, Hai Yan;
TP53 wild-type/PPM1D mutant diffuse intrinsic pontine gliomas are sensitive to a MDM2 antagonist.
Acta Neuropathol. Commun. 9:178.1-178.12(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_VU70
Cell_Model_Passport; SIDM01714
DepMap; ACH-002348
Encyclopedic resources Wikidata; Q94303494
Gene expression databases GEO; GSM4969594
GEO; GSM4969595
GEO; GSM4969596
GEO; GSM4969597
GEO; GSM4969623
GEO; GSM4969655
GEO; GSM4969656
GEO; GSM4969658
GEO; GSM4969662
GEO; GSM4969663
GEO; GSM4969664
GEO; GSM5356018
Entry history
Entry creation24-May-2019
Last entry update10-Apr-2025
Version number13