Cellosaurus logo
expasy logo

Cellosaurus HSJD-DIPG-007-NTC (CVCL_C1MT)

[Text][XML][JSON]
Cell line name HSJD-DIPG-007-NTC
Synonyms HSJD-DIPG-007 NTC
Accession CVCL_C1MT
Resource Identification Initiative To cite this cell line use: HSJD-DIPG-007-NTC (RRID:CVCL_C1MT)
Comments Characteristics: Control cell line for HSJD-DIPG-007-TP53 KO (Cellosaurus=CVCL_C1MU).
Derived from site: In situ; Brainstem, pons; UBERON=UBERON_0000988.
Sequence variations
  • Mutation; HGNC; HGNC:171; ACVR1; Simple; p.Arg206His (c.617G>A); ClinVar=VCV000018309; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:4764; H3-3A; Simple; p.Lys28Met (c.83A>T) (H3.3K27M); ClinVar=VCV000376435; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Pro428Glnfs*3 (c.1283delC); Zygosity=Unspecified (from parent cell line).
Disease Diffuse intrinsic pontine glioma (NCIt: C94764)
Diffuse intrinsic pontine glioma (ORDO: Orphanet_497188)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_VU70 (HSJD-DIPG-007)
Sex of cell Male
Age at sampling 6Y
Category Cancer cell line
STR profile Source(s): PubMed=34732238

Markers:
AmelogeninX,Y
CSF1PO10
D5S81813
D7S8209,12
D13S31713
D16S53913,14
D21S1129,30
TH016,9.3
TPOX8
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=32229503; DOI=10.1158/1541-7786.MCR-19-0507
Zhao-Hui Wang, Cheng Xu, Bill H. Diplas, Casey Joseph Moure, Chin-Pu Jason Chen, Lee H. Chen, Chang-Zheng Du, Hui-Shan Zhu, Paula K. Greer, Li-Wei Zhang, Yi-Ping He ...Show all 13 authors... , Matthew S. Waitkus, Hai Yan; Show fewer authors
Targeting mutant PPM1D sensitizes diffuse intrinsic pontine glioma cells to the PARP inhibitor olaparib.
Mol. Cancer Res. 18:968-980(2020)

PubMed=34732238; DOI=10.1186/s40478-021-01270-y; PMCID=PMC8565061
Cheng Xu, Heng Liu, Christopher J. Pirozzi, Lee H. Chen, Paula K. Greer, Bill H. Diplas, Li-Wei Zhang, Matthew S. Waitkus, Yi-Ping He, Hai Yan;
TP53 wild-type/PPM1D mutant diffuse intrinsic pontine gliomas are sensitive to a MDM2 antagonist.
Acta Neuropathol. Commun. 9:178.1-178.12(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C1MT
Encyclopedic resources Wikidata; Q114311662
Entry history
Entry creation22-Sep-2022
Last entry update19-Dec-2024
Version number6