Cellosaurus cell line CV-hIPS-B-APP-E693A clone 3d9 (CVCL

Cross-references
Cell line name	CV-hIPS-B-APP-E693A clone 3d9
Synonyms	GM25430-APP-E693A clone 3d9; 3d9
Accession	CVCL_VR53
Resource Identification Initiative	To cite this cell line use: CV-hIPS-B-APP-E693A clone 3d9 (RRID:CVCL_VR53)
Comments	Population: Caucasian. Derived from site: In situ; Arm, skin; UBERON=UBERON_0002427. Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations	Mutation; HGNC; HGNC:620; APP; Simple_edited; p.Glu693Ala (c.2078_2079AA>CC); Zygosity=Homozygous; Note=By CRISPR/Cas9 (PubMed=30686764).
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_1N86 (CV-hIPS-B)
Sex of cell	Male
Age at sampling	62Y
Category	Induced pluripotent stem cell
Publications	PubMed=30686764; DOI=10.1016/j.stem.2018.12.013; PMCID=PMC6414424 Rik van der Kant, Vanessa F. Langness, Cheryl M. Herrera, Daniel A. Williams, Lauren K. Fong, Yves Leestemaker, Evelyne Steenvoorden, Kevin D. Rynearson, Jos F. Brouwers, J. Bernd Helms, Huib Ovaa ...Show all 15 authors... , Martin Giera, Steven L. Wagner, Anne G. Bang, Lawrence Steven B. Goldstein; Show fewer authors Cholesterol metabolism is a druggable axis that independently regulates Tau and amyloid-beta in iPSC-derived Alzheimer's disease neurons. Cell Stem Cell 24:363-375.e9(2019)
Encyclopedic resources	Wikidata; Q93460584
Entry history
Entry creation	13-Nov-2018
Last entry update	19-Dec-2024
Version number	12