Cellosaurus cell line CV-hIPS-B-APP-E693A clone 2b2 (CVCL

Cross-references
Cell line name	CV-hIPS-B-APP-E693A clone 2b2
Synonyms	GM25430-APP-E693A clone 2b2; 2b2
Accession	CVCL_VR52
Resource Identification Initiative	To cite this cell line use: CV-hIPS-B-APP-E693A clone 2b2 (RRID:CVCL_VR52)
Comments	Population: Caucasian. Derived from site: In situ; Arm, skin; UBERON=UBERON_0002427. Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations	Mutation; HGNC; HGNC:620; APP; Simple_edited; p.Glu693Ala (c.2078_2079AA>CC); Zygosity=Homozygous; Note=By CRISPR/Cas9 (PubMed=30686764).
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_1N86 (CV-hIPS-B)
Sex of cell	Male
Age at sampling	62Y
Category	Induced pluripotent stem cell
Publications	PubMed=30686764; DOI=10.1016/j.stem.2018.12.013; PMCID=PMC6414424 Rik van der Kant, Vanessa F. Langness, Cheryl M. Herrera, Daniel A. Williams, Lauren K. Fong, Yves Leestemaker, Evelyne Steenvoorden, Kevin D. Rynearson, Jos F. Brouwers, J. Bernd Helms, Huib Ovaa ...Show all 15 authors... , Martin Giera, Steven L. Wagner, Anne G. Bang, Lawrence Steven B. Goldstein; Show fewer authors Cholesterol metabolism is a druggable axis that independently regulates Tau and amyloid-beta in iPSC-derived Alzheimer's disease neurons. Cell Stem Cell 24:363-375.e9(2019)
Encyclopedic resources	Wikidata; Q93460583
Entry history
Entry creation	13-Nov-2018
Last entry update	19-Dec-2024
Version number	12